About 30 results found for searched term "IDE 1" (0.004 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1839 | MDV3100 | Androgen Receptor |
| Enzalutamide; MDV-3100 | ||
| MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. | ||
| M1845 | LY335979 trihydrochloride | P-glycoprotein |
| Zosuquidar trihydrochloride; RS 33295-198 trihydrochloride | ||
| LY335979 (Zosuquidar trihydrochloride) is a selective Pgp (P-glycoprotein) inhibitor with a Ki of 59 nM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1945 | CAL-101 (Idelalisib) | PI3K |
| Idelalisib; GS-1101 | ||
| CAL-101 (Idelalisib; GS-1101) is an oral PI3Kδ-specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. | ||
| M1989 | CHIR-99021 HCl | GSK-3 |
| Laduviglusib hydrochloride; CHIR-99021 hydrochloride | ||
| CHIR-99021 HCl (Laduviglusib; CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2326 | Etoposide (VP-16-213) | Topoisomerase |
| VP-16-213; Vepesid; NSC 141540 | ||
| Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2408 | Atomoxetine hydrochloride | 5-HT Receptor |
| Tomoxetine hydrochloride; LY 139603; (R)-Tomoxetine hydrochloride | ||
| Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters. | ||
| M2809 | Levobetaxolol hydrochloride | Adrenergic Receptor |
| (S)-Betaxolol hydrochloride; AL-1577A | ||
| Levobetaxolol exhibits a higher affinity at cloned human β1 and β2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. | ||
| M2838 | Meptazinol hydrochloride | Opioid Receptor |
| IL-22811 hydrochloride; WY-22811 hydrochloride | ||
| Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. | ||
| M2929 | PF-4981517 | Cytochrome P450 (e.g. CYP17) |
| CYP3cide, PF-04981517 | ||
| PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. | ||
| M3002 | Scriptaid | HDAC |
| Scriptide; GCK1026 | ||
| Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3. | ||
| M3358 | Procainamide hydrochloride | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | ||
| Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. | ||
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M3547 | Glibenclamide | Others |
| Glyburide; RP-1127; BIIB093 | ||
| Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). | ||
| M3684 | Canertinib dihydrochloride | EGFR/HER2 |
| CI-1033 dihydrochloride, Canertinib 2HCl, PD-183805 dihydrochloride | ||
| Canertinib 2HCl is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. | ||
| M3708 | Anastrozole | Cytochrome P450 (e.g. CYP17) |
| Arimidex, ZD1033 | ||
| Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. | ||
| M3940 | Ginsenoside Rg1 | Amyloid |
| G-Rg1; Panaxoside Rg1 | ||
| Ginsenoside Rg1 is part of a class of triterpene saponins and steroid glycosides. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. It is found exclusively in the plant genus Panax, or ginseng. | ||
| M3987 | Ginsenoside Rb1 | Sodium Channel |
| Gynosaponin C; Gypenoside III | ||
| Ginsenoside Rb1 is an ingredient in the Chinese medicine Panax ginseng. Ginsenoside inhibition Na, K-ATPase++ activityIC50 6.3±1.0 μM. Ginsenoside Rb1 also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. | ||
| M1555 | Amyloid β-Peptide (1-42) human,TFA | Amyloid |
| Aβ1-42; β-Amyloid (1-42) | ||
| Amyloid β-Peptide (1-42) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. | ||
| M4053 | Mogroside-IIIA1 | Others |
| Mogroside III-A1 is a triterpenoid glycoside, which is a non-saccharide sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
| M4064 | Pseudoginsenoside-F11 | Metabolite/Endogenous Metabolite |
| Ginsenoside A1 | ||
| Pseudoginsenoside F11 (Ginsenoside A1), a component of Panax quinquefolium, can resist the learning and memory impairment induced by scopolamine, morphine and methamphetamine in mice. | ||
| M4069 | (S)Ginsenoside-Rh1 | PPAR |
| Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1; Ginsenoside-Rh1 | ||
| Ginsenoside Rh1 (Prosapogenin A2) inhibited the expression of PPAR-γ, TNF-α, IL-6 and IL-1β. | ||
| M4078 | (R)Ginsenoside-Rh1 | Others |
| (R)Ginsenoside-Rh1 is one of the important protopanaxatriol ginsenosides and has been reported to be the main hydrolysis product reaching the systemic circulation after oral ingestion of ginseng. | ||
| M4083 | Ginsenoside-F1 | Cytochrome P450 (e.g. CYP17) |
| 20(S)-Ginsenoside F1 | ||
| Ginsenoside F1 is an enzymatically modified derivative of Ginsenoside Rg1. Ginsenoside F1 competently inhibits CYP3A4 and has a weak inhibitory effect on CYP2D6. | ||
| M4092 | Ginsenoside-Rk1 | NF-κB |
| Ginsenoside Rk1 is a high-temperature processed extract of ginseng. Ginsenoside Rk1 has anti-inflammatory effects and inhibits Jak2/Stat3 signaling pathway and NF-κB activation. | ||
| M4101 | Notoginsenoside-R1 | Amyloid |
| Sanchinoside R1; Sanqi glucoside R1 | ||
| Notoginsenoside R1 (Sanchinoside R1) is a saponin isolated from P. notoginseng. Notoginsenoside R1 has antioxidant, anti-inflammatory, anti-angiogenic and anti-apoptotic activities. Notoginsenoside R1 provides cardiac protection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 may also provide neuroprotection. | ||
| M4102 | Notoginsenoside-Ft1 | HIF |
| Notoginsenoside Ft1(Notoginsenoside Ft1) is a plant isolated panax Notoginsenoside that stimulates angiogenesis. | ||
| M4117 | Hederacolchiside-A1 | PI3K |
| Hederacolchiside A1, isolated from Pulsatilla pulsatilla, induces apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro. | ||
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