About 30 results found for searched term "ICA" (0.005 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1709 | Everolimus | mTOR |
| RAD001, SDZ-RAD, Certican | ||
| Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM. | ||
| M1825 | PCI-32765 | BTK |
| Ibrutinib; CRA-032765 | ||
| PCI-32765 (Ibrutinib) is a potent, selective and orally bioavailable irreversible inhibitor of BTK with IC50 value of 0.46 nM. | ||
| M1910 | Nepicastat hydrochloride | Dopamine Receptor |
| SYN117 | ||
| Nepicastat hydrochloride is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, respectively. | ||
| M1923 | Lonidamine | CFTR |
| AF 1890；Diclondazolic Acid; DICA | ||
| Lonidamine (AF-1890) is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki=2.5 μM). | ||
| M1960 | Bicalutamide | Androgen Receptor |
| Bicalutamide is an orally active non-steroidal androgen receptor antagonist (IC50 = 190 nM). | ||
| M2600 | Balicatib | Cathepsin |
| AAE-581 | ||
| Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. | ||
| M2349 | (R)-Nepicastat hydrochloride | HCV Protease |
| RS-25560-198 HCl | ||
| (R)-Nepicastat hydrochloride, the R-enantiomer of Nepicastat hydrochloride, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. | ||
| M2392 | Ampiroxicam | COX |
| CP 65703 | ||
| Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound. | ||
| M2406 | Articaine hydrochloride | Animal experimental anesthetics |
| Ultracaine | ||
| Articaine hydrochloride is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue. Articaine hydrochloride ameliorates LPS-induced acute kidney injury via inhibition of NF-ĸB activation and the NLRP3 inflammasome pathway. | ||
| M2881 | Nicardipine hydrochloride | Calcium Channel |
| YC-93 Hydrochloride | ||
| Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders. | ||
| M3069 | Ticagrelor | P2 Receptor |
| AR-C 126532XX; AZD6140 | ||
| Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist with Ki of 2 nM respectively. | ||
| M3070 | Ticarcillin sodium | Antibiotic |
| Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. | ||
| M3181 | Nicaraven | Others |
| Nicaraven is a novel free radical scavenger, a calcium channel blocker. | ||
| M3203 | Lornoxicam | COX |
| Chlortenoxicam | ||
| Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively. | ||
| M3234 | (R)-Bicalutamide | Androgen Receptor |
| (R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells. | ||
| M3265 | Olmesartan | Angiotensin Receptor |
| RNH-6270 | ||
| Olmesartan is an angiotensin II receptor antagonist with an IC50 of 7.7 nM. | ||
| M3267 | Nepicastat | Others |
| SYN117, RS-25560-197 | ||
| Nepicastat is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ±0.8 and 9.0 ±0.8 nM for bovine and human, respectively. | ||
| M3297 | Meloxicam | Immunology/Inflammation |
| Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. | ||
| M3380 | Pitavastatin Calcium | Autophagy |
| Pitavastatin hemicalcium; NK-104 | ||
| Pitavastatin Calcium is a new type of statin. | ||
| M3429 | Piroxicam | COX |
| Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM. | ||
| M3521 | Fluticasone propionate | Animal Modeling |
| Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever). | ||
| M3669 | Micafungin Sodium | Antibiotic |
| FK463 sodium | ||
| Micafungin Sodium is an inhibitor of 1, 3-beta-D-glucan synthesis, it is an antifungal agent. | ||
| M3826 | Carica papaya protease | Enzymes & Coenzymes |
| Papain is a cysteine protease of the peptidase C1 family. | ||
| M3938 | Baicalin | GABA Receptor |
| Baicalein 7-O-β-D-glucuronide; 5, 6-dihydroxy-7-O-glucuronide flavone | ||
| Baicalin is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB. | ||
| M1634 | Chitin (practical grade) | Others |
| Chitin is a large, structural polysaccharide found in the cell walls of fungi, the exoskeletons of insects, and certain hard structures in fish and invertebrates. | ||
| M1545 | Infliximab | TNF Receptor |
| Remicade; Avakine; CT-P13 | ||
| Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. | ||
| M4030 | Crassicauline-A | Others |
| Crassicaulin A | ||
| Crassicauline A (Crassicaulin A) is A bioactive alkaloid in aconite roots. Crassicauline A (Crassicaulin A) had antifeedant activity against the adult Raptor, and its EC50 value was 1134.5 PPM. | ||
| M4062 | Punicalagin | Anti-infection |
| Punicalagin is a species from Punica Granatum L. Or polyphenols isolated from the leaves of Terminalia catappa L. Punicalagin is a reversible, noncompetitive 3CLpro inhibitor that inhibits SARS-COV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) drug with antioxidant, anti-inflammatory and anticancer effects. Punicalagin has the potential to be used in COVID-19 research. | ||
| M4063 | Punicalin | Others |
| Punicalin is a hydrolyzed tannin that can be obtained from Punica granatum L. Or from the leaves of Terminalia catappa L. Punicalin is an anti-hepatitis B virus (HBV) drug with anti-inflammatory activity. | ||
| M4184 | Cynarin | PI3K |
| 1,3-O-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid | ||
| 1, 3-dicaffeoylquinic acid is a derivative of caffeyl quinic acid, which has antioxidant activity and free radical scavenging activity. | ||
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