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Micafungin Sodium

Cat. No. M3669
Micafungin Sodium Structure
Synonym:

FK463 sodium

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 124  USD155 In stock
2mg USD 30.4  USD38 In stock
5mg USD 54.4  USD68 In stock
10mg USD 96  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Micafungin inhibits the synthesis of 1, 3-beta-D-glucan, an integral component of the fungal cell wall. Micafungin is not active against deoxyribonucleic acid, ribonucleic acid or protein synthesis in C. Micafungin is a potential agent for disrupting the structure of a biofilm of P. aeruginosa allowing the possible exposure and treatment of core-planktonic cells.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1292.26
Formula C56H70N9NaO23S
CAS Number 208538-73-2
Purity >98%
Solubility DMSO 30 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Bazzi W, et al. Biofouling. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa.

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