About 30 results found for searched term "Hs-1" (0.036 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3731 | HS-173 | PI3K |
| HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM. | ||
| M43838 | Almonertinib mesylate | EGFR/HER2 |
| HS-10296 mesylate | ||
| Almonertinib mesylate is an orally active, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitization and T790M resistance mutations, and also shows strong inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37, 0.29, and 0.21 nM, respectively. The IC50 of T790M/Del19 was 0.37, 0.29 and 0.21 nM, respectively, but the inhibitory effect on wild-type was weaker, with an IC50 of 3.39 nM. It can be used in the research of non-small cell lung cancer. | ||
| M7041 | NPPB | Chloride Channel |
| Hoechst 144; HOE 144 | ||
| NPPB is a blocker of the outwardly rectifying chloride channel (ORCC) with IC50 of 80 nM. NPPB has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization. | ||
| M11299 | Recombinant Mouse HSP60 Protein (E.coli, His) | Cytokines and Growth Factors |
| HSPD1 | ||
| Recombinant Mouse HSP60 Protein (E.coli, His) is a member of the chaperone protein family. HSP60 acts as a signaling molecule in the innate immune system. | ||
| M9246 | HUHS015 | Others |
| HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells. | ||
| M9258 | HS-1371 | RIPK |
| HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. | ||
| M9273 | HSP70-IN-1 | HSP |
| HSP70-IN-1 is a heat shock protein (HSP) inhibitor with an IC50 of 2.3 μM inhibiting the growth of Kasumi-1 cells. | ||
| M9299 | HSF1A | HSP |
| HSF1A is an activator of Heat shock transcription factor 1 (HSF1). | ||
| M9380 | Solutol HS-15 | Solvents & Excipients |
| Solutol HS-15 is a permeability enhancer. | ||
| M14135 | Almonertinib | EGFR/HER2 |
| HS-10296 | ||
| Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. | ||
| M14136 | Almonertinib hydrochloride | EGFR/HER2 |
| HS-10296 hydrochloride | ||
| Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. | ||
| M20430 | Adrenosterone | Others |
| Reichstein's substance G, 11-ketoandrostenedione, 11-oxoandrostenedione | ||
| Adrenosterone is endogenous steroid hormone that has been promoted as a dietary supplement capable of reducing body fat and increasing muscle mass. | ||
| M20550 | KHS101 hydrochloride | Microtubule |
| KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks. | ||
| M20805 | DTHIB | HSP |
| Direct Targeted HSF1 InhiBitor | ||
| DTHIB is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities. | ||
| M21118 | HSK16149 | Calcium Channel |
| HSK16149 is an oral γ-aminobutyric acid analog and a novel voltage-gated calcium channel (VGCC) α2δ subunit ligand for studies related to diabetic peripheral neuralgia (DPNP). | ||
| M21554 | Recombinant Human FGF-4 (E. coli) | Cytokines and Growth Factors |
| HBGF-4; HST; HST-1; HSTF1; K-FGF; KFGF | ||
| Fibroblast growth factor-4 (FGF-4), also known as K-FGF, is a heparin-bound growth factor in the FGF family. It is identified by its carcinogenic transforming activity. Accession # P08620. | ||
| M21707 | Recombinant Mouse HSP70 Protein (HEK293, His Tag) | Cytokines and Growth Factors |
| HSPA1A; heat shock 70kDa protein 1A | ||
| HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. The Hsp70 family stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. | ||
| M25502 | NHS-PEG1-SS-PEG1-NHS | Cell Transfection |
| NHS-PEG1-SS-PEG1-NHS is a reversible linker for biomacromolecule link with active small molecule. NHS-PEG1-SS-PEG1-NHS can be used in proteins liposomes or nanoparticles. | ||
| M25538 | Recombinant Human SEPHS1 (HEK293, C-6His) | Cytokines and Growth Factors |
| Selenide; Selenophosphate synthase 1 | ||
| Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. SEPHS1 can be activated by phosphate ions and by potassium ions. | ||
| M28088 | KHS101 | Others |
| KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation. | ||
| M28870 | Vutiglabridin | Others |
| HSG4112 | ||
| Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability. | ||
| M29309 | Chst15-IN-1 | Others |
| Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair. | ||
| M29470 | Anrikefon | Opioid Receptor |
| HSK21542 | ||
| Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect. | ||
| M29719 | Anrikefon acetate | Opioid Receptor |
| HSK21542 acetate | ||
| Anrikefon (HSK21542) acetate is a kappa opioid receptor agonist with analgesic effect. | ||
| M29822 | Aha1/Hsp90-IN-1 | Microtubule |
| Aha1/Hsp90-IN-1 (Compound 17) is an Aha1/Hsp90 complex inhibitor. Aha1/Hsp90-IN-1 disrupts Aha1/Hsp90 interactions with an IC50 of 3.32 μM. Aha1/Hsp90-IN-1 inhibits tau aggregation. | ||
| M31380 | Recombinant Human HSP70 Protein (HEK293, N-His) | Cytokines and Growth Factors |
| HSP70-2; HSP72; HSPA1 | ||
| HSP70 can serve a cytokine function to initiate both innate and adaptive immunity through activation of APC. HSP serves also a chaperone function and facilitates the presentation of antigen peptide to T cells. | ||
| M41214 | HSP90-IN-21 | Parasite |
| HSP90-IN-21 (5e) is an antiplasmodial agent, with IC50 values of 0.04, 0.17 and 2.91 μM against erythrocytic stage of P. | ||
| M42274 | HSD17B13-IN-2 | Dehydrogenase |
| HSD17B13-IN-2 is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. | ||
| M42275 | HSD17B13-IN-3 | Dehydrogenase |
| HSD17B13-IN-3 is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor. | ||
| M42352 | 17β-HSD10-IN-2 | Metabolite/Endogenous Metabolite |
| 17β-HSD10-IN-2 is a benzothiazolylurea-based inhibitor, targeting to 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10), a multifunctional mitochondrial enzyme. | ||
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