Free shipping on all orders over $ 500

Almonertinib

Cat. No. M14135
Almonertinib Structure
Synonym:

HS-10296

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 380  USD380 In stock
25mg USD 720  USD720 In stock
50mg USD 980  USD980 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

Chemical Information
Molecular Weight 525.64
CAS Number 1899921-05-1
Solubility (25°C) DMSO ≥ 83.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuhan Zhang, et al. Effect of almonertinib on the proliferation, invasion, and migration in non-small cell lung cancer cells

[2] Faisal A Almalki, et al. Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR

[3] Ting Jiang, et al. Almonertinib-induced interstitial lung disease: A case report

[4] Misako Nagasaka, et al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC

[5] James Chih-Hsin Yang, et al. Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial

Related EGFR/HER2 Products
Almonertinib mesylate

Almonertinib mesylate is an orally active, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitization and T790M resistance mutations, and also shows strong inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37, 0.29, and 0.21 nM, respectively. The IC50 of T790M/Del19 was 0.37, 0.29 and 0.21 nM, respectively, but the inhibitory effect on wild-type was weaker, with an IC50 of 3.39 nM. It can be used in the research of non-small cell lung cancer.

MAPK-IN-2

MAPK-IN-2 is a potent MAPK inhibitor with antineoplastic activity.

EGFR-IN-81

EGFR-IN-81 is an EGFR inhibitor.

EGFR-IN-85

EGFR-IN-85 is an EGFR inhibitor.

JGK-068S

JGK-068S is a potent EGFR inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Almonertinib, HS-10296 supplier, EGFR/HER2, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.