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Almonertinib

Cat. No. M14135

All AbMole products are for research use only, cannot be used for human consumption.

Almonertinib Structure
Synonym:

HS-10296

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 380  USD380 In stock
25mg USD 720  USD720 In stock
50mg USD 980  USD980 In stock
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Quality Control & Documentation
Biological Activity

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

Chemical Information
Molecular Weight 525.64
CAS Number 1899921-05-1
Solubility (25°C) DMSO ≥ 83.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yuhan Zhang, et al. Effect of almonertinib on the proliferation, invasion, and migration in non-small cell lung cancer cells

[2] Faisal A Almalki, et al. Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR

[3] Ting Jiang, et al. Almonertinib-induced interstitial lung disease: A case report

[4] Misako Nagasaka, et al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC

[5] James Chih-Hsin Yang, et al. Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial

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  Catalog
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Keywords: Almonertinib, HS-10296 supplier, EGFR/HER2, inhibitors, activators

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