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Recombinant Human SEPHS1 (Mammalian, C-6His)

Cat. No. M25538
Recombinant Human SEPHS1 (Mammalian, C-6His) Structure
Synonym:

Selenide; Selenophosphate synthase 1

Size Price Availability Quantity
10ug USD 280  USD280 In stock
50ug USD 750  USD750 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. SEPHS1 can be activated by phosphate ions and by potassium ions. SEPHS1 has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased.

Recombinant Human SEPHS1 is produced by Mammalian expression system and expressed the target gene encoding Met1-Ser392 with a 6His tag at the C-terminus.


Accession: P49903

APMol Mass: 42 KDa, reducing conditions

Endotoxin <1 EU/µg

Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 100mM glycine, 10% Glycerol, pH 7.3.

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Storage Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Flore Oudouhou, et al. Biochemistry. Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43

[2] So-Young Choi, et al. Clin Exp Med. Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization

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Keywords: Recombinant Human SEPHS1 (Mammalian, C-6His), Selenide; Selenophosphate synthase 1 supplier, Recombinant Proteins, inhibitors, activators


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