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Almonertinib hydrochloride

Cat. No. M14136

All AbMole products are for research use only, cannot be used for human consumption.

Almonertinib hydrochloride Structure
Synonym:

HS-10296 hydrochloride

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Quality Control & Documentation
Biological Activity

Almonertinib (HS-10296) hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib hydrochloride shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib hydrochloride is used for the research of the non-small cell lung cancer.

Chemical Information
Molecular Weight 562.11
CAS Number 2134096-03-8
Solubility (25°C) DMSO 83.33 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
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Keywords: Almonertinib hydrochloride, HS-10296 hydrochloride supplier, EGFR/HER2, inhibitors, activators

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