All AbMole products are for research use only, cannot be used for human consumption.
Species: Human
Expression system: E. coli
Purity: SDS-PAGE analysis > 95%, HPLC analysis > 95%
Endotoxin: Protein content < 0.2 EU/μg was determined by gel coagulation
Apparent molecular weight: ~19.4 kDa, reduced by SDS-PAGE
Storage and stability: Upon receipt, the product remains stable at temperatures below -70°C for up to 6 months. After reconstruction, the product should be stable at 4°C for up to 1 week or at -20°C for up to 3 months. For long-term storage, the addition of a carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles.
Bioactivity: ED50 < 0.5 ng/ml, measured in cell proliferation assay using 3T3 cells, corresponds to > 2.0 × 10 6 units /mg of specific activity. Fibroblast growth factor-4 (FGF-4), also known as K-FGF, is a heparin-bound growth factor in the FGF family. It is identified by its carcinogenic transforming activity. FGF-4 and FGF-3 are located on chromosome 11. FGF-4 and its receptors (FGF-R1C, 2c, 3c and 4) play an important role in the regulation of embryonic development, cell proliferation and cell differentiation. FGF-4 is required for normal limb and heart valve development during embryogenesis.
| Solubility (25°C) | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] No authors listed. BioDrugs. FGF-4 gene therapy GENERX--Collateral Therapeutics
| Related Cytokines and Growth Factors Products |
|---|
| Recombinant Human FGF-8b Protein (E. coli)
Recombinant Human FGF-8b Protein is a heparin-binding growth factor, which plays a core role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and other effect. |
| Recombinant Rat GDNF Protein (Baculovirus-Insect, N-His)
GDNF is an important member of the GDNF family of ligands. GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. |
| Recombinant Rat PDGF-BB (E. coli)
Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. |
| Recombinant Human ApoE3 Protein (HEK293, C-6His)
ApoE is a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. |
| Recombinant Mouse Granzyme B (HEK293, C-6His)
Granzyme B (GZMB) is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
