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Recombinant Human EPO Protein (HEK293, C-His)

Cat. No. M9241
Recombinant Human EPO Protein (HEK293, C-His) Structure


Size Price Availability Quantity
50ug USD 390  USD390 In stock
100ug USD 665  USD665 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
Biological Activity

Erythropoietin (EPO) is a glycoprotein hormone known primarily for its role in erythropoiesis, which is responsible for stimulating the proliferation and differentiation of erythroid progenitor cells. Cfu-e cells can differentiate into red blood cells only in the presence of EPO. The physiological levels of EPO in adult mammals are mainly maintained by the kidneys, while in fetal or newborn mammals, EPO levels are maintained by the liver. EPO also performs a variety of non-hematopoietic activities, including vascularization and smooth muscle proliferation, neuroprotection during hypoxia, and stimulation of certain B cells.

DNA sequence encoding human EPO (NP_000790.2) expressed with a His tag at the C-terminus.

Recombinant human EPO protein contains 172 amino acids with a predicted molecular weight of 19.2kD.

Measured by cell proliferation assay with TF-1 cells, the ED50 of this effect is ≤5 ng/mL.

Endotoxin: < 0.1EU/μg

Product Citations
Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Middleton SA, et al. J Biol Chem. Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.

[2] Livnah O, et al. Nat Struct Biol. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.

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Keywords: Recombinant Human EPO Protein (HEK293, C-His), Erythropoietin supplier, Recombinant Proteins, inhibitors, activators

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