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Recombinant Human EPO Protein (CHO)

Cat. No. M9241

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human EPO Protein (CHO) Structure
Synonym:

Erythropoietin

Size Price Availability Quantity
10ug USD 90  USD90 In stock
50ug USD 390  USD390 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin <0.2 EU/ug
  • COA
  • MSDS
Biological Activity

Erythropoietin (EPO) is a glycoprotein hormone known primarily for its role in erythropoiesis, which is responsible for stimulating the proliferation and differentiation of erythroid progenitor cells. Cfu-e cells can differentiate into red blood cells only in the presence of EPO. The physiological levels of EPO in adult mammals are mainly maintained by the kidneys, while in fetal or newborn mammals, EPO levels are maintained by the liver. EPO also performs a variety of non-hematopoietic activities, including vascularization and smooth muscle proliferation, neuroprotection during hypoxia, and stimulation of certain B cells.

DNA sequence encoding human EPO (Ala28-Arg193) expressed.

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells, the ED50 is < 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 106 units/mg.


Accession: P01588

Endotoxin < 0.2 EU/µg

Apparent Molecular Weight: 26~36 kDa, reducing conditions

Lyophilized from sterile PBS, pH 7.4.

Product Citations
Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Middleton SA, et al. J Biol Chem. Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.

[2] Livnah O, et al. Nat Struct Biol. An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.

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Keywords: Recombinant Human EPO Protein (CHO), Erythropoietin supplier, Cytokines and Growth Factors, inhibitors, activators

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