About 30 results found for searched term "F-1" (0.002 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1644 | AG-014699 phosphate | PARP |
| PF-01367338, Rucaparib phosphate | ||
| AG-014699 (PF-01367338, Rucaparib) is a PARP inhibitor with a Ki of 1.4 nM. | ||
| M1673 | Nintedanib | VEGFR/PDGFR |
| BIBF1120; Intedanib | ||
| Nintedanib (BIBF1120) is a novel, potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively. | ||
| M1721 | AZD4547 | FGFR |
| Fexagratinib; ABSK091 | ||
| AZD4547 is a potent, selective and orally active pan-FGFR inhibitor with IC50s of 0.2. 2.5, 1.8 and 165 nM for FGFR1, 2, 3 and 4, respectively. | ||
| M1765 | Crizotinib (PF-02341066) | c-Met |
| Crizotinib | ||
| Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. | ||
| M1766 | PF-04217903 | c-Met |
| PF-4217903 | ||
| PF-04217903 (PF-4217903) is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to142 nM. | ||
| M1772 | PKI-587 | PI3K |
| Gedatolisib; PF-05212384 | ||
| PKI-587 (Gedatolisib; PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with the IC50 value of 0.4nM. | ||
| M1831 | Cyclosporine A | Immunology/Inflammation |
| Ciclosporin A; CsA; Cyclosporin A; Antibiotic S 7481F1 | ||
| Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. | ||
| M1898 | Plerixafor (AMD3100) | CXCR |
| AMD3100; JM3100; ID791; AMD-3329 | ||
| Plerixafor (AMD3100) is a CXCR4 chemokine receptor antagonist. | ||
| M1923 | Lonidamine | CFTR |
| AF 1890；Diclondazolic Acid; DICA | ||
| Lonidamine (AF-1890) is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki=2.5 μM). | ||
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M1984 | PF-04691502 | PI3K |
| PF-04691502 is a potent and selective, ATP-competitive PI3K/mTOR inhibitor with IC50 of 7.5 nM and 3.8 nM of AKT T308 and AKT S473, respectively. | ||
| M2003 | PF-04929113 | HSP |
| SNX-5422 | ||
| PF-04929113 (SNX-5422) is a potent and selective Hsp90 inhibitor with Kd of 41 nM. SNX-5422 (PF-04929113) also induces Her-2 degradation, with an IC50 of 37 nM. | ||
| M2006 | Safinamide Mesylate | Monoamine Oxidase |
| FCE28073, PNU-151774E, NW-1015 | ||
| Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2028 | Fludarabine | STAT |
| Fludara; NSC 118218; Fludarabinum; F-ara-A | ||
| Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. | ||
| M2040 | BAY 11-7082 | IκB/IKK |
| BAY 11-7821; NF-κB inhibitor 13 | ||
| BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). | ||
| M2057 | Dexrazoxane hydrochloride | Topoisomerase |
| Cardioxane, ICRF-187, NSC169780, Zinecard，DXZ | ||
| Dexrazoxane HCl (ICRF-187, ADR-529, DXZ) is an iron chelator that can be used to prevent DOX-induced cardiotoxicity. | ||
| M10334 | FF-10101 | FLT3 |
| FF-10101-01 | ||
| FF-10101 is a novel irreversible FLT3 inhibitor. | ||
| M2109 | AZD3463 | ALK |
| ALK/IGF1R inhibitor | ||
| AZD3463 is a novel ALK/IGF1R inhibitor with IC50 value of 22 nM. | ||
| M2144 | Topotecan hydrochloride | Topoisomerase |
| Hycamtin; NSC 609669; SKF 104864A hydrochloride | ||
| Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. | ||
| M2160 | Reboxetine mesylate | Adrenergic Receptor |
| FCE20124 mesylate; PNU155950E mesylate | ||
| Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and > 10000 nM for rat NET, SERT and DAT respectively). | ||
| M2197 | Sulfasalazine | Ferroptosis |
| Salazopyrin; Azulfidine; Sulphasalazine; SAS; NSC 667219 | ||
| Sulfasalazine is a sulfonamide agent derived from Mesalazine. Sulfasalazine has xC-system inhibitory activity associated with iron death and is primarily used as an anti-inflammatory agent. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer. | ||
| M2220 | GDC-0941 Bimesylate | PI3K |
| Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC-0941 | ||
| GDC-0941 Bimesylate is the orally bioavailable bismesylate salt of a potent inhibitor of the class I phosphatidylinositol 3 kinase (PI3K). | ||
| M2254 | Gatifloxacin | Antibiotic |
| Gatiflo; AM-1155; BMS-206584; PD135432 | ||
| Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family. | ||
| M2271 | PF-4708671 | S6 Kinase |
| PF-04708671 | ||
| PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM. PF4708671 inhibits MSK1 (IC50 of 0.95 μM) 4-fold more weakly than S6K1. | ||
| M2302 | PF-562271 | FAK |
| PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. | ||
| M2428 | BAF312 | S1P Receptor |
| Siponimod | ||
| BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. | ||
| M2504 | CFTR(inh)-172 | CFTR |
| CFTR inhibitor 172 | ||
| CFTR(inh)-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. | ||
| M2614 | DBeQ | p97 |
| JRF 12 | ||
| DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. | ||
| M2698 | Ferrostatin-1 | Ferroptosis |
| Fer-1 | ||
| Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM. | ||
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