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Reboxetine mesylate is a potent, selective, and specific norepinephrine reuptake inhibitor. Reboxetine has weak affinity (Ki > 1,000 nmol/L) for muscarinic, histaminergic H1, adrenergic alpha1, and dopaminergic D2 receptors. Repeated administration of reboxetine (5.6 mg/kg) decreased nicotine self-administration and sucrose-maintained responding across the 14 sessions, suggesting that tolerance did not develop to these effects of reboxetine. Additionally, reboxetine did not alter baseline locomotor activity, indicating that the decrease in operant responding for nicotine and sucrose was not the result of a nonspecific decrease in activity. The reboxetine-induced decrease in nicotine self-administration and sucrose-maintained responding may be the result of inhibition of norepinephrine transporters and/or neuronal nicotinic receptor function.
| Molecular Weight | 409.5 |
| Formula | C19H23NO3.CH3SO3H |
| CAS Number | 98769-84-7 |
| Solubility (25°C) | DMSO 75 mg/mL Water 35 mg/mL |
| Storage | 2-8°C |
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