About 30 results found for searched term "AMG-1" (0.027 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2383 | AMG-517 | TRP Channel |
| AMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. | ||
| M1595 | Evolocumab | PCSK9 |
| AMG 145 ； Repatha | ||
| Evolocumab (AMG 145) is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. | ||
| M6433 | AMG 21629 | TRP Channel |
| AMG 21629 is a potent and selective TRPV1 antagonist. | ||
| M6437 | AMG 9810 | TRP Channel |
| AMG 9810 is a potent and selective, competitive antagonist of TRPV1. | ||
| M8984 | Denosumab | NF-κB |
| AMG 162,Anti-RANK ligand | ||
| Denosumab is designed to target RANKL (RANK ligand), a protein that acts as the primary signal to promote bone removal/resorption. | ||
| M9356 | AMG-510 (Sotorasib) | Ras |
| Sotorasib; AMG510 | ||
| AMG-510 (Sotorasib) is a potent KRAS G12C covalent inhibitor. | ||
| M9357 | AMG-510 racemate | Ras |
| AMG-510 racemate is a racemic of AMG-510, which is a potent KRAS G12C covalent inhibitor. | ||
| M10139 | Anakinra | IL Receptor/Related |
| Raleukin; AMG-719 | ||
| Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. | ||
| M11306 | Etelcalcetide hydrochloride | Calcium-sensing Receptor |
| AMG 416 hydrochloride; KAI-4169 hydrochloride | ||
| Etelcalcetide Hydrochloride (AMG 416 Hydrochloride) is a synthetic peptide that acts as a calcium-sensitive receptor (CaSR) activator. Etelcalcetide hydrochloride effectively reduces parathyroid hormone (PTH) concentration in patients with secondary hyperparathyroidism undergoing hemodialysis. | ||
| M13380 | Tapotoclax | Bcl-2 |
| AMG-176；CS-2836 | ||
| Tapotoclax is an inhibitor of myeloid leukemia cell differentiation protein McL-1 (myeloid leukemia-1) with a Ki value of 0.13 nM and has potential pro-apoptotic and anti-tumor activity. | ||
| M13384 | Kira8 | IRE1 |
| AMG-18 | ||
| Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM. | ||
| M20610 | AMG319 | PI3K |
| AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. | ||
| M20743 | AMG-1 | c-Met |
| c-Met/RON Dual Kinase Inhibitor, RON-IN-1 | ||
| AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. | ||
| M21307 | Romiplostim | Thrombopoietin/Thrombin |
| Romiplate; AMG531 | ||
| Romiplostim binds to and activates the TPO receptor on megakaryocyte precursors, thus promoting cell proliferation and viability, resulting in increased platelet production. | ||
| M24530 | Solitomab | Others |
| AMG 110; MT110 | ||
| Solitomab (AMG 110) is a bispecific anti-CD3 and anti-epithelial-cell-adhesion-molecule (EpCAM) antibody. Solitomab can be used for the research of primary uterine and ovarian carcinosarcoma cancer. | ||
| M24675 | Pasotuxizumab | PSMA |
| BAY 2010112; AMG 212 | ||
| Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC). | ||
| M24719 | Tezepelumab | Others |
| AMG 157; MEDI 19929; zz-ekko | ||
| Tezepelumab (AMG 157) is a first-in-class human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma. | ||
| M24999 | Zelminemab | Others |
| AMG-301 | ||
| Zelminemab (AMG-301) is a human monoclonal antibody that inhibits PACAP type I (PAC1) receptor. | ||
| M25041 | Pavurutamab | Others |
| AMG-701 | ||
| Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on AMG-420 . The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM). | ||
| M25125 | Vepsitamab | Others |
| AMG 199 | ||
| Vepsitamab (AMG 199) is an anti-MUC17/CD3 BiTE antibody that binds to CD3 on T cells and MUC17 expressed on tumor cells, mediates redirected tumor cell lysis, and induces T cell activation and proliferation. | ||
| M25126 | Gresonitamab | Others |
| AMG 910; Anti-Human CD3xClaudin18 2 | ||
| Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and CLDN18.2-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma. | ||
| M25161 | Rocatinlimab | TNF Receptor |
| AMG 451; KHK4083 | ||
| Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD). | ||
| M25260 | Rilotumumab | c-Met |
| AMG 102 | ||
| Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research. | ||
| M25262 | Ordesekimab | IL Receptor/Related |
| AMG 714; PRV-015 | ||
| Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD). | ||
| M25270 | Conatumumab | TNF Receptor |
| AMG 655; TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant Antibody | ||
| Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. . | ||
| M25276 | Ganitumab | IGF-1R |
| AMG 479; Human Anti-IGF1R Recombinant Antibody | ||
| Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer. | ||
| M27787 | AMG-221 | Hydroxysteroid dehydrogenase |
| AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes. | ||
| M27963 | AMG-8718 | Gamma-secretase/Beta-secretase |
| AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain. | ||
| M28089 | Etelcalcetide | Calcium-sensing Receptor |
| AMG 416; KAI-4169 | ||
| Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis. | ||
| M28249 | AMG-1694 | Glucokinase (GK) |
| AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals. | ||
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