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Ordesekimab

Cat. No. M25262

All AbMole products are for research use only, cannot be used for human consumption.

Ordesekimab Structure
Synonym:

AMG 714; PRV-015

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Quality Control & Documentation
Biological Activity

Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD).

Chemical Information
CAS Number 879293-15-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Yu-Ling Wei, et al. J Immunotoxicol. Strategies to evaluate potential effector function of glycan variants: a case study of ordesekimab (AMG 714 or PRV-015)

[2] Marja-Leena Lähdeaho, et al. Lancet Gastroenterol Hepatol. Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: a phase 2a, randomised, double-blind, placebo-controlled study

[3] Satya Kurada, et al. Expert Rev Clin Pharmacol. Current and novel therapeutic strategies in celiac disease

[4] Herve Lebrec, et al. J Immunol. Homeostasis of human NK cells is not IL-15 dependent

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Keywords: Ordesekimab, AMG 714; PRV-015 supplier, IL Receptor/Related, inhibitors, activators

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