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Romiplostim

Cat. No. M21307
Romiplostim Structure
Synonym:

Romiplate; AMG531

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
50mg USD 250  USD250 In stock
100mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Romiplostim binds to and activates the TPO receptor on megakaryocyte precursors, thus promoting cell proliferation and viability, resulting in increased platelet production.

Chemical Information
Molecular Weight 238.28
Formula C15H14N2O
CAS Number 267639-76-9
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] James B Bussel, et al. Drug Des Devel Ther. A Review of Romiplostim Mechanism of Action and Clinical Applicability

[2] Hanny Al-Samkari, et al. Haematologica. A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies

[3] Gerald A Soff, et al. J Clin Oncol. Romiplostim Treatment of Chemotherapy-Induced Thrombocytopenia

[4] David J Kuter. Cancer Treat Res. Romiplostim

[5] James E Frampton, et al. Drugs. Romiplostim

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Keywords: Romiplostim, Romiplate; AMG531 supplier, Thrombopoietin/Thrombin, inhibitors, activators


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