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AMG-8718 

Cat. No. M27963

All AbMole products are for research use only, cannot be used for human consumption.

AMG-8718  Structure

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Quality Control & Documentation
Biological Activity

AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain.

Chemical Information
Molecular Weight 442.44
Formula C25H19FN4O3
CAS Number 1215868-94-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Thomas A Dineen, et al. J Med Chem. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)

[2] Mark R Fielden, et al. Toxicol Pathol. Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

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  Catalog
Abmole Inhibitor Catalog




Keywords: AMG-8718  supplier, Gamma-secretase/Beta-secretase, inhibitors, activators

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