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AMG-1

Cat. No. M20743
AMG-1 Structure
Synonym:

c-Met/RON Dual Kinase Inhibitor, RON-IN-1

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 556.58
Formula C31H29FN4O5
CAS Number 913376-84-8
Purity >99%
Solubility DMSO 100 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog




Keywords: AMG-1, c-Met/RON Dual Kinase Inhibitor, RON-IN-1 supplier, c-Met, inhibitors

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