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Cat. No. M20743
AMG-1 Structure

c-Met/RON Dual Kinase Inhibitor, RON-IN-1

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Biological Activity

AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.

Chemical Information
Molecular Weight 556.58
Formula C31H29FN4O5
CAS Number 913376-84-8
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Yingjun Sun, et al. Chemistry. Interfacial Engineering in PtNiCo/NiCoS Nanowires for Enhanced Electrocatalysis and Electroanalysis

[2] L Liu, et al. Yao Xue Xue Bao. [Effect of AMG-1 and adenosine on glutamate release from synaptosomes in rats]

[3] A Magistrelli, et al. Drug Metab Dispos. Fate of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET18-OME) in malignant cells, normal cells, and isolated and perfused rat liver

[4] H Araki, et al. Methods Find Exp Clin Pharmacol. The adenosine analogue and cerebral protecting agent, AMG-1, has no effect on delayed neuronal death following ischemia

[5] F B Solodkov, et al. Med Tekh. [AMG-1 myographic analyzer]

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Keywords: AMG-1, c-Met/RON Dual Kinase Inhibitor, RON-IN-1 supplier, c-Met, inhibitors, activators

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