About 31 results found for searched term "5-HT Receptor" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41730 | 5-HT2A receptor agonist-3 | 5-HT Receptor |
| 5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM. | ||
| M1930 | Granisetron hydrochloride | 5-HT Receptor |
| BRL-43694, Kytril | ||
| Granisetron hydrochloride is a potent and selective 5-HT3 receptor antagonist that possesses potent antiemetic activity. | ||
| M2048 | Sumatriptan succinate | 5-HT Receptor |
| GR-43175 | ||
| Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. | ||
| M2134 | Vortioxetine hydrobromide | 5-HT Receptor |
| Lu AA21004 | ||
| Vortioxetine hydrobromide (Lu AA21004) is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist and a 5-HT transporter (5-HTT) inhibitor in vitro. | ||
| M2146 | Prucalopride | 5-HT Receptor |
| Prucalopride is a potent, selective and specific serotonin 5-HT4 receptor agonist with enterokinetic properties. | ||
| M2175 | Palonosetron hydrochloride | 5-HT Receptor |
| Palonosetron hydrochloride is a novel antiemetic 5-HT3-receptor antagonist. | ||
| M2230 | Agomelatine | Melatonin Receptor |
| Valdoxan; Melitor; S-20098 | ||
| Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. Agomelatine is also a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. | ||
| M2266 | Pizotifen malate | 5-HT Receptor |
| Sandomigran, pizotyline | ||
| Pizotifen malate is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. | ||
| M2388 | Amitriptyline hydrochloride | 5-HT Receptor |
| Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively. | ||
| M2470 | BRL-54443 | 5-HT Receptor |
| BRL 54443 is a 5-HT1E and 5-HT1F receptor agonist with pKi of 8.7 and 9.25, respectively, witha weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. | ||
| M2664 | Eletriptan hydrobromide | 5-HT Receptor |
| UK-116044 | ||
| Eletriptan is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively. | ||
| M2678 | Equol | Estrogen Receptor |
| Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. | ||
| M2704 | Flopropione | 5-HT Receptor |
| Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist. Flopropione is also a catechol-o-methyltransferase (COMT) inhibitor. | ||
| M2821 | Lorcaserin hydrochloride | 5-HT Receptor |
| APD356 | ||
| Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. | ||
| M2965 | Prucalopride Succinat | 5-HT Receptor |
| R-108512 | ||
| Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively. | ||
| M2966 | PRX-08066 Maleic acid | 5-HT Receptor |
| PRX-08066 Maleate | ||
| PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. | ||
| M2999 | SB271046 | 5-HT Receptor |
| SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. | ||
| M3000 | Intepirdine | 5-HT Receptor |
| GSK 742457; SB-742457; RVT-101 | ||
| Intepirdine (SB742457) is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. | ||
| M3004 | Serotonin hydrochloride | 5-HT Receptor |
| 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride | ||
| Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. | ||
| M3127 | VUF 10166 | 5-HT Receptor |
| VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. | ||
| M3160 | Vilazodone | 5-HT Receptor |
| EMD 68843, SB 659746A | ||
| Verazodone (EMD 68843; SB 659746A) is a complex serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently being evaluated in clinical studies for major depression. | ||
| M3201 | Azasetron dihydrochloride | 5-HT Receptor |
| Y-25130 2HCl; SENS-401 dihydrochloride | ||
| Azasetron dihydrochloride is the hydrochloride form of Azasetron and is also an orally active 5-HT3 receptor antagonist for studies related to ear disorders such as sudden hearing loss. | ||
| M3211 | Ondansetron | 5-HT Receptor |
| GR 38032F, GR-C507/75 | ||
| Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. | ||
| M3223 | LY310762 | 5-HT Receptor |
| LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor. | ||
| M3239 | Ketanserin | 5-HT Receptor |
| R41468 | ||
| Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. | ||
| M3320 | Quetiapine Fumarate | 5-HT Receptor |
| Quetiapine hemifumarate | ||
| Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. | ||
| M3363 | RS-127445 | 5-HT Receptor |
| MT500 | ||
| RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. | ||
| M3374 | Zolmitriptan | 5-HT Receptor |
| BW-311C90; 311C90 | ||
| Zolmitriptan is a 5-HT1B/1D-angiotensin receptor (5-HT1B/1D-AR) partial agonist with Ki's of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, and 5-HT1F receptors, respectively.Zolmitriptan can be used in studies related to migraine. | ||
| M3414 | Olanzapine | 5-HT Receptor |
| LY170053 | ||
| Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. | ||
| M3417 | Clozapine | 5-HT Receptor |
| HF 1854 | ||
| Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. | ||
| M3479 | Aripiprazole | 5-HT Receptor |
| OPC-14597 | ||
| Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. Aripiprazole (OPC-14597) is a potent and high-affinity dopamine D2 receptor partial agonist. | ||
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