| Cat.No. | Name | Information |
|---|---|---|
| M3648 | HO-3867 | HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3970 | Scutellarin | Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. |
| M2883 | Nifuroxazide | Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| M2028 | Fludarabine | Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| M3032 | Stattic | Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
| M7747 | Diosgenin | Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. |
| M4433 | Alantolactone | Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone (helenin, helenine, Eupatal) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. |
| M9706 | Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M10077 | Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M3928 | Scoparone | Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. |
| M3922 | Gracillin | Gracillin is a glycoside, more particularly to a Spirostanol saponin, which can be found among others in many plants of the genus Dioscorea, Paris and Costacea, for example in tamus communis. |
| M3664 | SH-4-54 | SH-4-54 is a potent STAT inhibitor with KD values of 300 nM and 464 nM for STAT3 and STAT5, respectively. |
| M1782 | NSC 74859 (S3I-201) | NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM. NSC 74859 (S3I-201) is effective in hepatocellular cancers with disrupted TGF-beta signaling.*The compound is unstable in solutions, freshly prepared is recommended |
| M1293 | Artesunate | Artesunate is a potential STAT3 inhibitor that acts on the small cell lung cancer cell line H69 with an IC50 value of < 5 μM and is also used in antimalarial studies. Artesunate also promotes ROS signaling and lipid peroxidation by increasing the formation of variable iron pools, ultimately leading to iron death in pancreatic cancer cells. |
| M56430 | HP590 | HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). |
| M56429 | 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea | STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. |
| M55305 | HJC0123 | HJC0123 is a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs. HJC0123 reduced the phosphorylation, nuclear translocation, and transcriptional activity of STAT3. HJC0123 treatment resulted in the inhibition of HSCs proliferation at submicromolar concentrations. It decreased the expression of STAT3-regulated proteins, induced cell cycle arrest, promoted apoptosis and downregulated SOCS3. |
| M55304 | ODZ10117 | ODZ10117 is a small molecule inhibitor of STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells. |
| M55298 | OPB-111077 | OPB-111077 is a first-in-class, novel, oral inhibitor of STAT3 and mitochondrial oxidative phosphorylation (OXPHOS) with anticancer activity. OPB-111077 inhibits mitochondrial respiratory chain complex I, which leads to inhibition of energy production and activation of the AMPK-mTOR energy stress sensor pathway. |
| M55297 | OPB-31121 | OPB-31121 is a novel STAT inhibitor which strongly inhibited STAT3 and STAT5 phosphorylation without upstream kinase inhibition, and induced significant growth inhibition in various hematopoietic malignant cells. |
| M52823 | STAT3-IN-21, cell-permeable, negative control | STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection. |
| M52822 | STAT3-IN-24, cell-permeable | STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor. |
| M52821 | 5-FAM-GpYLPQTV-NH2 | 5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. |
| M52820 | Ac-GpYLPQTV-NH2 | Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM. |
| M49690 | XZH-5 | XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability. |
| M49689 | STAT6-IN-1 | STAT6-IN-1 is a STAT6 inhibitor with a high affinity for the SH2 domain of STAT6 (IC50=0.028 µM). |
| M49688 | STAT3-SH2 domain inhibitor 1 | STAT3-SH2 domain inhibitor 1 is a potent Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain) inhibitor with a Kd value of 1.57 μM. |
| M49687 | STAT3-IN-8 | STAT3-IN-8 is a potent STAT3 inhibitor. |
| M49686 | STAT3-IN-7 | STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. |
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