Free shipping on all orders over $ 500

Colivelin

Cat. No. M10077

All AbMole products are for research use only, cannot be used for human consumption.

Colivelin Structure
Synonym:

CLN

Size Price Availability Quantity
500ug USD 155  USD155 In stock
1mg USD 245  USD245 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. Colivelin suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.

Product Citations
Chemical Information
Molecular Weight 2645.13
Formula C119H206N32O35
CAS Number 867021-83-8
Solubility (25°C) DMSO 50 mg/mL
Water ≥ 1 mg/mL
Storage -20°C, dry, sealed
References

[1] Hui Zhao, et al. Neuroscience. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway

Related STAT Products
HP590 

HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM).

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3.

HJC0123

HJC0123 is a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs. HJC0123 reduced the phosphorylation, nuclear translocation, and transcriptional activity of STAT3. HJC0123 treatment resulted in the inhibition of HSCs proliferation at submicromolar concentrations. It decreased the expression of STAT3-regulated proteins, induced cell cycle arrest, promoted apoptosis and downregulated SOCS3.

ODZ10117

ODZ10117 is a small molecule inhibitor of STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells.

OPB-111077

OPB-111077 is a first-in-class, novel, oral inhibitor of STAT3 and mitochondrial oxidative phosphorylation (OXPHOS) with anticancer activity. OPB-111077 inhibits mitochondrial respiratory chain complex I, which leads to inhibition of energy production and activation of the AMPK-mTOR energy stress sensor pathway.

  Catalog
Abmole Inhibitor Catalog




Keywords: Colivelin, CLN supplier, STAT, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.