All AbMole products are for research use only, cannot be used for human consumption.
Niclosamide (trade name Niclocide) is a teniacide in the anthelmintic family. Niclosamide inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. It does not decrease the level or activity of the related STAT1, STAT5, JAK or Src kinases. Niclosamide also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. Niclosamide inhibits the proliferation and colony formation of Du145 prostate cancer cells, which have constitutively active STAT3, with IC50 values of 0.7 and 0.1 μM, respectively.
Int Immunopharmacol. 2024 Feb 15;128:111563.
Regulation of IL-10 expression and function by JAK-STAT in CD8+ T cells
Niclosamide purchased from AbMole
Cont Lens Anterior Eye. 2024 Nov 29.
In vitro killing effect of berberine and niclosamide on ocular Demodex folliculorum
Niclosamide purchased from AbMole
| Molecular Weight | 327.12 |
| Formula | C13H8Cl2N2O4 |
| CAS Number | 50-65-7 |
| Solubility (25°C) | DMF 4 mg/mL DMSO 3.5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related STAT Products |
|---|
| HP590
HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). |
| 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. |
| HJC0123
HJC0123 is a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs. HJC0123 reduced the phosphorylation, nuclear translocation, and transcriptional activity of STAT3. HJC0123 treatment resulted in the inhibition of HSCs proliferation at submicromolar concentrations. It decreased the expression of STAT3-regulated proteins, induced cell cycle arrest, promoted apoptosis and downregulated SOCS3. |
| ODZ10117
ODZ10117 is a small molecule inhibitor of STAT3. ODZ10117 inhibited migration and invasion and induced apoptotic cell death by targeting STAT3 in glioblastoma cells. |
| OPB-111077
OPB-111077 is a first-in-class, novel, oral inhibitor of STAT3 and mitochondrial oxidative phosphorylation (OXPHOS) with anticancer activity. OPB-111077 inhibits mitochondrial respiratory chain complex I, which leads to inhibition of energy production and activation of the AMPK-mTOR energy stress sensor pathway. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
