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HO-3867 is a selective STAT3 inhibitor. HO-3867 blocks the JAK/STAT3 pathway in human ovarian cancer cell lines. HO-3867/cisplatin combination treatment significantly inhibites cisplatin-resistant cell proliferation in a concentration-dependent manner. HO-3867 induces G(2)-M cell cycle arrest in A2780 cells. HO-3867 promotes apoptosis by caspase-8 and caspase-3 activation.
APMIS. 2015 Oct;837-46.
Leukemia inhibitory factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3.
HO-3867 purchased from AbMole
2015 May.
Study on IL-17(A) in Regulating Omentum Metastasis and Drug Resistance of Ovarian Cancer
HO-3867 purchased from AbMole
. figure 4..jpg) |
Source | APMIS (2015). Figure 4. HO-3867 (Abmole Bioscience, Shanghai, China) |
| Method | The cellular growth, colony formation, and invasion assay | |
| Cell Lines | 143B cells | |
| Concentrations | ||
| Incubation Time | 24 h | |
| Results | In 143B cells, the cellular growth, colony formation, and invasion enhanced by LIF were partially neutralized by HO-3867 (Fig. 4B–D, p = 0.04, 0.016 and 0.05, respectively). |
| Cell Experiment | |
|---|---|
| Cell lines | A2780 (A2780R), PA-1, SKOV3, OV4, and OVCAR3 cells; human ovarian surface epithelial cell |
| Preparation method | Determining cell viability by a colorimetric assay using MTT. In the mitochondria of living cells, yellow MTT undergoes a reductive conversion to formazan, producing a purple color. Cells, grown to ~80% confluence in 75-mm flasks, are trypsinized, counted, seeded in 96-well plates with an average population of 7,000 cells/well, incubated overnight, and then treated with HO-3867 for 24 h. All experiments are done using 8 replicates and repeated at least three times. |
| Concentrations | ~20 μM |
| Incubation time | 24 hours |
| Animal Experiment | |
|---|---|
| Animal models | Mice bearing ovarian cancer A2780 tumor xenografts |
| Formulation | |
| Dosages | ~100 ppm |
| Administration | p.o. |
| Molecular Weight | 464.55 |
| Formula | C28H30F2N2O2 |
| CAS Number | 1172133-28-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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