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Colivelin TFA

Cat. No. M9706
Colivelin TFA Structure
Size Price Availability Quantity
500ug USD 180  USD180 In stock
1mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. Colivelin TFA suppresses neuronal death by activating STAT3 in vitro. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.

Product Citations
Chemical Information
Molecular Weight 2759.12
Formula C119H206N32O35.C2HF3O2
Solubility (25°C) Water 50 mg/mL
Storage -20°C, dry, sealed, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ying-Ying Fang, et al. Int J Neurosci. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia

[2] Hui Zhao, et al. Neuroscience. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway

[3] Tomohiro Chiba, et al. J Neurosci. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimers disease-relevant insults in vitro and in vivo

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Keywords: Colivelin TFA supplier, STAT, inhibitors, activators


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