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Colivelin TFA

Cat. No. M9706

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Colivelin TFA Structure
Size Price Availability Quantity
500ug USD 155  USD155 In stock
1mg USD 245  USD245 In stock
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Quality Control & Documentation
Biological Activity

Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. Colivelin TFA suppresses neuronal death by activating STAT3 in vitro. Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.

Product Citations
Chemical Information
Molecular Weight 2759.12
Formula C119H206N32O35.C2HF3O2
CAS Number 2803948-60-7
Solubility (25°C) Water 50 mg/mL
Storage -20°C, dry, sealed
References

[1] Ying-Ying Fang, et al. Int J Neurosci. MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia

[2] Hui Zhao, et al. Neuroscience. Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway

[3] Tomohiro Chiba, et al. J Neurosci. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimers disease-relevant insults in vitro and in vivo

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Keywords: Colivelin TFA supplier, STAT, inhibitors, activators

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