| Cat.No. | Name | Information |
|---|---|---|
| M3648 | HO-3867 | HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. |
| M3982 | Cryptotanshinone | Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity. |
| M3970 | Scutellarin | Scutellarin, an active flavone isolated from Scutellaria baicalensis, is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited caspase-11 activation and pyroptosis in macrophages at least partly via regulating the PKA signaling pathway. |
| M2883 | Nifuroxazide | Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells. |
| M2028 | Fludarabine | Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. |
| M3032 | Stattic | Stattic is the first nonpeptidic STAT3 inhibitor, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Stattic inhibits STAT3 phosphorylation (at Y705 and S727). |
| M7747 | Diosgenin | Diosgenin is a plant steroid which induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. |
| M4433 | Alantolactone | Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone (helenin, helenine, Eupatal) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction. |
| M9706 | Colivelin TFA | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M10077 | Colivelin | Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3. |
| M49665 | CMD178 | CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. |
| M49664 | APT STAT3 | APT STAT3 is a specific STAT3-binding peptide. |
| M49663 | Antitumor agent-73 | Antitumor agent-73 is a Diosgenin derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. |
| M49662 | Angoline hydrochloride | Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. |
| M49660 | STX-0119 | STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM. |
| M49659 | MNK8 | MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. |
| M49657 | LLL12 | LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. |
| M49655 | HP590 | HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). |
| M49652 | CMD178 TFA | CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. |
| M49507 | W1131 TFA | W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. |
| M43967 | WB436B | WB436B is a potent, highly selective small molecule inhibitor of STAT3 that specifically targets the STAT3-SH2 structural domain with a KD value of 94.3 nM. |
| M42114 | STAT6-IN-3 | STAT6-IN-3 is a STAT6 inhibitor (IC50= 44 nM). |
| M42113 | STAT6-IN-2 | STAT6-IN-2 is an inhibitor of STAT6. |
| M42112 | STAT3 degrader-2 | STAT3 degrader-2 is a PROTAC-based degrader of STAT3. |
| M42111 | HJC0416 | HJC0416 is a potent and orally active STAT3 inhibitor. |
| M42110 | STAT3-IN-20 | STAT3-IN-20 is a selective STAT3 inhibitor (IC50: 0.65 μM). |
| M42109 | 8-Epixanthatin | 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. |
| M42108 | 7-epi-Isogarcinol | 7-epi-Isogarcinol is a polycyclic polyprenylated acylphloroglucinol (PPAP), with moderate antiproliferative activity. |
| M40553 | CLXR-005 | CLXR-005 is a STAT6 inhibitor that can be used in studies related to breast cancer. |
| M39011 | W1131 | W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway. |
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