All AbMole products are for research use only, cannot be used for human consumption.
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively. Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor α (TNFα), interleukin-1β (IL-1β) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFα, and IL-1β mRNA expression in rat primary microglia or BV-2 mouse microglial cell line. Scutellarin inhibited LPS-induced nuclear translocation and DNA binding activity of nuclear factor κB (NF-κB). Scutellarin dose-dependently inhibited intracellular LPS-induced release of caspase-11p26 (indicative of caspase-11 activation) and generation of N-terminal fragment of gasdermin D (GSDMD-NT), leading to reduced pyroptosis in macrophages. Scutellarin also suppressed LPS-induced caspase-11 activation and pyroptosis in RAW 264.7 cells lacking ASC expression.
Int J Clin Exp Pathol. 2020 Feb 1;13(2):212-219.
Scutellarin circumvents chemoresistance, promotes apoptosis, and represses tumor growth by HDAC/miR-34a-mediated down-modulation of Akt/mTOR and NF-κB-orchestrated signaling pathways in multiple myeloma
Scutellarin purchased from AbMole
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Source | Int J Clin Exp Pathol 2020 Feb. Figure 1. Scutellarin (Abmole Bioscience, USA) |
| Method | tail vein | |
| Cell Lines | BALB/C nude mice | |
| Concentrations | 60 mg/kg | |
| Incubation Time | - | |
| Results | Staining of the tumor sections with H&E revealed loss of cellular architecture with hypercellularity in the controls, while BTB+STN treatment depicted significant pyknosis, compared to BTB or STN treated mice. |
| Molecular Weight | 462.36 |
| Formula | C21H18O12 |
| CAS Number | 27740-01-8 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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