| Cat.No. | Name | Information |
|---|---|---|
| M9573 | Orexin A (human, mouse, rat, bovine) | Orexin A (human, mouse, rat, bovine) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. |
| M3261 | Almorexant | Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. |
| M40751 | Nemorexant hydrochloride | Nemorexant hydrochloride is an orally active dual orexin type 1 and type 2 (OX1 and OX2) receptor antagonist (DORA) as well as an inhibitor of BCRP, with an IC50 value of 3.0 μM when acting on BCRP, and can be used in studies related to insomnia. |
| M25479 | [Ala11,D-Leu15]-Orexin B (human) acetate | [Ala11,D-Leu15]-Orexin B (human) acetate is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B (human) acetate shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (EC50=52 nM). |
| M25478 | Orexin B, human TFA | Orexin B, human TFA is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
| M25477 | Orexin B, rat, mouse TFA | Orexin B, rat, mouse TFA is an endogenous orexin receptor agonist. Orexin B, rat, mouse TFA binds and activates two closely related orphan G protein-coupled receptors OX1-R and OX2-R. |
| M25026 | Cudarolimab | Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research. |
| M25015 | Revdofilimab | Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells. |
| M14038 | Seltorexant | Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). |
| M14036 | Orexin A (human, rat, mouse) (TFA) | Orexin A human, rat, mouse TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. |
| M14035 | EMPA | EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. |
| M14034 | Almorexant hydrochloride | Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively. |
| M10955 | Nemorexant | Nemorexant (ACT-541468) is an effective orexin receptor antagonist. It also has IC50s of 2 nM and 3 nM for the Ox1 receptor and Ox2 receptor, respectively. |
| M9943 | OXA (17-33) | OXA (17-33) is a potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). |
| M9855 | Orexin 2 Receptor Agonist | Orexin 2 Receptor Agonist (ABM-565520) is a potent and selective Orexin2 receptor agonist with EC50 value of 23 nM. |
| M9839 | Lemborexant | Lemborexant (E-2006) is an orally active, competitive and reversible dual OX1 and OX2 receptors antagonist, with IC50 values of 6.1 nM and 2.6 nM, respectively. |
| M8997 | MK-1064 | MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for the research of insomnia. |
| M8966 | SB-649868 | SB-649868 is a selective orally active orexin (OX) receptor antagonist with pKi values of 9.4 and 9.5 at the OX1 and OX2 receptor, respectively. |
| M7396 | TCS-OX2-29 | TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. |
| M7263 | SB 334867 | SB 334867 is a selective non-peptide OX 1 antagonist. |
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