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TCS-OX2-29

Cat. No. M7396

All AbMole products are for research use only, cannot be used for human consumption.

TCS-OX2-29 Structure
Size Price Availability Quantity
5mg USD 77  USD77 In stock
10mg USD 113  USD113 In stock
25mg USD 205  USD205 In stock
50mg USD 310  USD310 In stock
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Quality Control & Documentation
Biological Activity

TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.

Chemical Information
Molecular Weight 397.51
Formula C23H31N3O3
CAS Number 372523-75-6
Solubility (25°C) DMSO 20 mg/mL
Ethanol 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Urwyler, et al. Neuropharmacology. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I Pharmacological characterization in vitro.

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Keywords: TCS-OX2-29 supplier, OX Receptor, inhibitors, activators

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