Cat.No. | Name | Information |
---|---|---|
M9573 | Orexin A (human, mouse, rat, bovine) | Orexin A (human, mouse, rat, bovine) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. |
M3261 | Almorexant | Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. |
M28902 | Fazamorexant | Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research. |
M28892 | YNT-185 dihydrochloride | YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models. |
M28891 | YNT-185 | YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models. |
M24761 | Efizonerimod alfa | Efizonerimod alfa is a potent monoclonal antibody OX40 activator. Efizonerimod alfa can be used for cancer research. |
M21590 | Vornorexant | Vornorexant (ORN-0829; TS-142) is an effective dual antagonist of OX1R and OX2R, with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant has shown effective sleep promotion in animal models and can be used to study insomnia. |
M21270 | JNJ-54717793 | JNJ-54717793 is a selective octreotide-1 receptor antagonist used in studies of anxiety disorders, unlike the dual octreotide-1/2 inhibitors and octreotide-2 inhibitors typically used in sleep disorders. |
M21068 | Danavorexton | Danavorexton is a CNS-permeable, injectable OX2 agonist. |
M14039 | Seltorexant hydrochloride | Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). |
M14037 | Orexin receptor antagonist 3 | Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist. |
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