| Cat.No. | Name | Information |
|---|---|---|
| M9573 | Orexin A (human, mouse, rat, bovine) | Orexin A (human, mouse, rat, bovine) is a specific, high-affinity agonist for G-protein-coupled receptor OX1R. |
| M3261 | Almorexant | Almorexant is a competitive OX1 and OX2 orexin receptor antagonist with IC50 of 13 and 8 nM, respectively. |
| M3710 | MK-3697 | MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
| M3324 | SB408124 | SB408124 (Tocris-1963) is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. |
| M2124 | MK-6096 | MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX(1)R and OX(2)R. |
| M54494 | [Ala11, D-Leu15]-Orexin B(human) | [Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. |
| M54469 | Orexin B, rat, mouse | Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
| M52942 | Hypocretin (70-98), human | Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis. |
| M52941 | Xenopus orexin A | Xenopus orexin A is a neuropeptides that identified as an endogenous ligands for an orphan G-protein-coupled receptor. |
| M52940 | Xenopus orexin B | Xenopus orexin B is a neuropeptides that identified as an endogenous ligands for an orphan G-protein-coupled receptor. |
| M52939 | Orexin B, human | Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
| M50234 | CVN766 | CVN766 is an oral small molecule orexin 1 receptor (Ox1R) antagonist that is approximately 1000 times more selective for Ox1R than Ox2R. |
| M41898 | Orexin receptor modulator-1 | Orexin receptor modulator-1 is an orexin receptor modulator. |
| M41897 | RTIOXA-43 | RTIOXA-43 is a orexin receptor agonist with EC50s of 24 nM and 24 nM for OX2 and OX1 receptors, respectively. |
| M41896 | Firazorexton hydrate | Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). |
| M29477 | Firazorexton | Firazorexton is a potent orexin type 2 receptor (OX2R) agonist. |
| M29476 | Suntinorexton | Suntinorexton, a heterocyclic compound, is an orexin type 2 receptor agonist. |
| M28902 | Fazamorexant | Fazamorexant (YZJ-1139) is a potent orexin receptor antagonist. Fazamorexant can be used for insomnia research. |
| M28892 | YNT-185 dihydrochloride | YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models. |
| M28891 | YNT-185 | YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models. |
| M25026 | Cudarolimab | Cudarolimab (IBI101) is a completely human anti-OX40 (CD134, a co stimulating molecule expressed by activated immune cells) antibody. Cudarolimab inhibits the binding of OX40 to its ligand OX40L. Cudarolimab has antitumor activity and can be used in cancer related research. |
| M25015 | Revdofilimab | Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells. |
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