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Vornorexant (ORN-0829; TS-142) is an effective dual antagonist of OX1R and OX2R, with IC50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant has shown effective sleep promotion in animal models and can be used to study insomnia.
| Molecular Weight | 447.47 |
| Formula | C23H22FN7O2 |
| CAS Number | 1517965-94-4 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related OX Receptor Products |
|---|
| CVN766
CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC50 values of 8 nM and >10 μM for OX1R and OX2R, respectively. |
| Nivasorexant
Nivasorexant is a potent orexin receptor antagonist. |
| [Ala11, D-Leu15]-Orexin B(human)
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. |
| Orexin B, rat, mouse
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
| Hypocretin (70-98), human
Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis. |
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