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MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for the research of insomnia. MK-1064 promotes sleep and increases both rapid eye movement (REM) and non-REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. Similar to dual antagonists, MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy.
Molecular Weight | 461.9 |
Formula | C24H20ClN5O3 |
CAS Number | 1207253-08-4 |
Solubility (25°C) | DMSO 10 mM |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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