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Seltorexant

Cat. No. M14038

All AbMole products are for research use only, cannot be used for human consumption.

Seltorexant Structure
Synonym:

JNJ-42847922

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 120  USD120 In stock
25mg USD 175  USD175 In stock
50mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

Chemical Information
Molecular Weight 407.44
CAS Number 1293281-49-8
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Manish Kumar Jha. Selective Orexin Receptor Antagonists as Novel Augmentation Treatments for Major Depressive Disorder: Evidence for Safety and Efficacy From a Phase 2B Study of Seltorexant

[2] Adam Savitz, et al. Efficacy and Safety of Seltorexant as Adjunctive Therapy in Major Depressive Disorder: A Phase 2b, Randomized, Placebo-Controlled, Adaptive Dose-Finding Study

[3] Clemens Muehlan, et al. Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders

[4] Kasper Recourt, et al. The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

[5] Sander Brooks, et al. The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia

Related OX Receptor Products
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CVN766 is an orally active inhibitor of orexin 1 receptor antagonist with blood-brain permeability with the IC50 values of 8 nM and >10 μM for OX1R and OX2R, respectively.

Nivasorexant

Nivasorexant is a potent orexin receptor antagonist.

[Ala11, D-Leu15]-Orexin B(human)

[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist.

Orexin B, rat, mouse

Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Hypocretin (70-98), human

Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis.

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Keywords: Seltorexant, JNJ-42847922 supplier, OX Receptor, inhibitors, activators

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