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Orexin 2 Receptor Agonist

Cat. No. M9855
Orexin 2 Receptor Agonist Structure
Synonym:

ABM-565520

Size Price Availability Quantity
10mg USD 222  USD222 In stock
25mg USD 462  USD462 In stock
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Quality Control & Documentation
Biological Activity

Orexin 2 Receptor Agonist is a potent and selective Orexin2 receptor agonist with EC50 value of 23 nM. Orexin 2 Receptor Agonist (ABM-565520) exhibits an orexin agonist activity and is expected to be useful as an excellent therapeutic or preventive agent for narcolepsy.

Chemical Information
Molecular Weight 586.7
Formula C32H34N4O5S
CAS Number 1796565-52-0
Solubility (25°C) DMSO 29 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Takashi Nagahara, et al. J Med Chem. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

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  Catalog
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Keywords: Orexin 2 Receptor Agonist, ABM-565520 supplier, OX Receptor, inhibitors, activators


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