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MAGL Monoacylglycerol Lipase

Inhibitors

Cat.No.  Name Information
M21136 ABD957 ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, inhibiting IC50 at an IC50 of 0.21 µM. ABD957 impaired N-Ras depalmitylation in AML cells, reducing N-Ras signaling and the growth of NRAS mutant AML cells.
M21099 MAGLi 432 MAGLi 432 is a novel, reversible inhibitor of monoacylglycerol lipase (MAGL).
M13413 JNJ-42226314 JNJ-42226314 is a competitive, highly selective and reversible inhibitor of non-covalent monoacylglycerol lipase (MAGL). The IC50s of JNJ-42226314 against human Hela cells, human PBMC, mouse brain and rat brain [1] were 1.13 nM, 1.88 nM, 0.67 nM and 0.97 nM, respectively.
M13370 KML-29 KML29 is an effective selective MAGL inhibitor with IC50 values of 15 nM, 43 nM and 5.9 nM in mice, rats and humans, respectively. KML29 has minimal cross-reaction with other central and peripheral serine hydrolases including FAAH.
M13369 ABX-1431 ABX-1431 is a highly potent, selective and orally available CNS-osmotic monacylglycerol lipase (MAGL) inhibitor with IC50 values of 14 nM and 27 nM against human and mouse MGLL, respectively.
M8689 JJKK-048 JJKK-048 is a cell penetrant ultrapotent and highly selective inhibitor of monoacylglycerol lipase (MAGL) that exhibits a low cross-reactivity with other endocannabinoid targets.
M8414 MJN110 MJN110 is an orally effective and selective inhibitor of monacylglycerol lipase (MAGL) with IC50 of 9.1 nM and 2.1 nM against hMAGL and 2-arachidonic triglyceride (2-AG), respectively. It has strong anti-hyperalgesia activity.
M6853 JW 642 Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively.
M4890 JZL 195 JZL195 is an effective FAAH and MAGL inhibitor with IC50 of 2 nM and 4 nM, respectively.
M2788 JZL184 JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.



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