| Cat.No. | Name | Information |
|---|---|---|
| M29986 | MAGL-IN-5 | MAGL-IN-5 (CAY10499) is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively. |
| M13370 | KML-29 | KML29 is an effective selective MAGL inhibitor with IC50 values of 15 nM, 43 nM and 5.9 nM in mice, rats and humans, respectively. KML29 has minimal cross-reaction with other central and peripheral serine hydrolases including FAAH. |
| M13369 | ABX-1431 | ABX-1431 is a highly potent, selective and orally available CNS-osmotic monacylglycerol lipase (MAGL) inhibitor with IC50 values of 14 nM and 27 nM against human and mouse MGLL, respectively. |
| M8689 | JJKK-048 | JJKK-048 is a cell penetrant ultrapotent and highly selective inhibitor of monoacylglycerol lipase (MAGL) that exhibits a low cross-reactivity with other endocannabinoid targets. |
| M8414 | MJN110 | MJN110 is an orally effective and selective inhibitor of monacylglycerol lipase (MAGL) with IC50 of 9.1 nM and 2.1 nM against hMAGL and 2-arachidonic triglyceride (2-AG), respectively. It has strong anti-hyperalgesia activity. |
| M6853 | JW 642 | Jw642 is a highly effective selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6 nM, 14 nM and 3.7 nM in mouse, rat and human meninges, respectively. |
| M4890 | JZL 195 | JZL195 is an effective FAAH and MAGL inhibitor with IC50 of 2 nM and 4 nM, respectively. |
| M2788 | JZL184 | JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM. |
| M56712 | MAGL-IN-4 | MAGL-IN-4 is an orally active, selective and reversible monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 6.2 nM. |
| M42495 | ABC34 | ABC34 is an inactive control compound of JJH260. |
| M42494 | Dimepiperate | Dimepiperate (MY 93) is a thiocarbamate (TC) pesticide. |
| M42493 | WWL123 | WWL123, a carbamate-based compound, is a potent and selective ABHD6 inhibitor. |
| M42492 | DH-376 | DH-376 is a potent diacylglycerol lipase inhibitor with pIC50 values of 8.6 and 8.9 for ABHD6 and DAGLα, respectively. |
| M29617 | MAGL-IN-6 | MAGL-IN-6 is a potent MAGL inhibitor with an IC50 of 4.71 nM. MAGL-IN-6 can be used for neurological disorders research (WO2020065613A1; example 234). |
| M29167 | PF-06795071 | PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM. |
| M28981 | MGL-IN-1 | MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant. |
| M28794 | JZP-MA-11 | JZP-MA-11 is a positron emission tomography (PET) ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. JZP-MA-11 can cross the blood-brain barrier (BBB). [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP). |
| M28702 | LEI-106 | LEI-106 is a potent, dual sn-1-Diacylglycerol lipase α (DAGL-α)/ABHD6 inhibitor with an IC50 of 18 nM for DAGL-α and a Ki of 0.8 μM for ABHD6. LEI-106 inhibits the hydrolysis of [14C]-sn-1-oleoyl-2-arachidonoyl-glycerol, the natural substrate of DAGL-α, with a Ki of 0.7 μM. |
| M28514 | KT185 | KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells. |
| M27967 | SAR629 | SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation. |
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