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JZL184

Cat. No. M2788
JZL184 Structure
Size Price Availability Quantity
10mg USD 65  USD65 In stock
50mg USD 240  USD240 In stock
100mg USD 410  USD410 In stock
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Quality Control & Documentation
Biological Activity

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

Chemical Information
Molecular Weight 520.49
Formula C27H24N2O9
CAS Number 1101854-58-3
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Melike Demir altekin, et al. The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats

[2] Jan Lukas Prser, et al. The Monoacylglycerol Lipase Inhibitor JZL184 Inhibits Lung Cancer Cell Invasion and Metastasis via the CB 1 Cannabinoid Receptor

[3] Jing Xu, et al. JZL184 protects hippocampal neurons from oxygen-glucose deprivation-induced injury via activating Nrf2/ARE signaling pathway

[4] Silvia Marino, et al. JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice

[5] Stephen G Woodhams, et al. The cannabinoid system and pain

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  Catalog
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Keywords: JZL184 supplier, MAGL, inhibitors, activators


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