| Cat.No. | Name | Information |
|---|---|---|
| M2347 | (+)-Bicuculline | (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. |
| M5442 | Baclofen | Baclofen is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research. |
| M5653 | Flumazenil | Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses. |
| M56486 | NCS-382 | NCS-382 is a potent GABA receptor antagonist and also a GHBR receptor antagonist. |
| M56485 | CGS 8216 | CGS 8216, a benzodiazepine receptor antagonist, inhibits 3H-flunitrazepam (3H-FLU) binding to rat synaptosomal membranes in vitro at subnanomolar concentrations. |
| M56484 | CGP13501 | CGP13501 is a positive allosteric modulator of GABAB receptor. |
| M56483 | TPA-023B | TPA-023B is a high-affinity and orally active GABAA receptor α2/α3 subtype (Kis of 0.73 nM/2 nM) partial agonist and a α1 subtype (Ki of 1.8 nM) antagonist. |
| M56482 | CGP46381 | CGP 46381 is an orally active GABAB receptor antagonist with IC50 of 4.9 μM. |
| M56481 | CGP35348 | CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. |
| M56480 | SCH 50911 | SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. |
| M56479 | Phaclofen | Phaclofen is a selective GABAB receptor antagonist. |
| M56478 | Lorediplon | Lorediplon is a novel non-benzodiazepine drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep. |
| M56477 | Lesogaberan | Lesogaberan (AZD-3355) is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. |
| M56476 | 3-Methyl-GABA | 3-Methyl-GABA is a potent GABA aminotransferase activator. |
| M56475 | CI-966 hydrochloride | CI-966 hydrochloride is a potent, selective, orally active and brain-penetrant inhibitor of the GABA transporter GAT-1, with IC50s of 0.26 μM and 1.2 μM for hGAT-1, rGAT-1, respectively. |
| M56474 | CGP36216 hydrochloride | CGP36216 hydrochloride is a selective antagonist at GABA presynaptic receptor. |
| M56473 | SCH 50911 hydrochloride | SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. |
| M56472 | Lesogaberan napadisylate | Lesogaberan (AZD-3355) napadisylate is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. |
| M56471 | Lesogaberan hydrochloride | Lesogaberan (AZD-3355) hydrochloride is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptor. |
| M56470 | Loreclezole hydrochloride | Loreclezole hydrochloride, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors. |
| M56469 | 6,2'-Dihydroxyflavone | 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. |
| M56468 | Tetrahydrodeoxycorticosterone | Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. |
| M54859 | Alogabat | Alogabat (RG-7816) is a GABAA α5 receptor positive allosteric modulators (PAMs). |
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