| Cat.No. | Name | Information |
|---|---|---|
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| M5158 | Tauroursodeoxycholic acid (Ursodoxicoltaurine) | Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. |
| M4037 | Astragaloside IV | Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. |
| M9688 | ERK5-IN-2 | ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. |
| M9510 | JWG-071 | JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. |
| M9300 | AG 126 | AG 126 is a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. |
| M9108 | AZD-0364 | Tizaterkib (AZD0364) is a potent and selective ERK2 inhibitor with an IC50 of 0.6 nM. |
| M8666 | Urolithin A | Urolithin A is a naturally occurring compound produced by the metabolism in the body of vegetable tannins (ellagic acid and ellagitannins) found in food. It is also a mitochondrial modulator, regulating mitochondrial function in hematopoietic stem cells, as well as restoring blood regeneration in aging hematopoietic stem cells. In addition, Urolithin A is a ligand for the Aromatic Hydrocarbon Receptor (AhR), which promotes the anti-tumor function of CD8+ cytotoxic T-lymphocytes (CTLs) in an AhR-independent manner. Moreover, Urolithin A directly binds to ERK1/2 kinase, enhances its activation, and subsequently phosphorylates and activates the autophagy initiation factor ULK1, thereby promoting autophagy. |
| M7792 | EF-24 | EF-24 is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI50 values of 0.7 μM and 0.8 μM, respectively. |
| M6266 | Pluripotin | Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. |
| M6235 | VX-11e | VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested. |
| M6089 | XMD8-92 | XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM. |
| M5345 | Ulixertinib (BVD-523) | VRT752271 (BVD-523, Ulixertinib) is an orally available, highly selective, ATP-competitive, reversible ERK1/2 inhibitor with an IC50 of <0.3 nM for ERK2 inhibition. |
| M5340 | Tauroursodeoxycholate Sodium | Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. |
| M5248 | DEL-22379 | DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
| M4819 | XMD17-109 | XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. |
| M4662 | Nitidine chloride | Nitidine chloride is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum with anti-malarial activity. |
| M4280 | Corynoxeine | Corynoxeine, isolated from the hook of Uncaria Rhynchophylla, is a potent ERK1/ERK 2 inhibitor in the proliferation of PDGF-BB induced vascular smooth muscle cells (VSMCs). |
| M3668 | GDC-0994 | Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with IC50 of 6.1 nM and 3.1 nM against ERK1 and ERK2, respectively. |
| M3642 | FR 180204 | FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. |
| M56431 | ERK Inhibitor II (Negative control) | ERK Inhibitor II (Negative control) is an effective inhibitor of extracellular signal-regulated kinase (ERK). |
| M54220 | PACAP-38 (31-38), human, mouse, rat | PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. |
| M52818 | Endothelin-1 (1-31) (Human) | Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. |
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