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AG 126 is a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. AG 126 selectively inhibits the phosphorylation. AG126 can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).
| Molecular Weight | 215.17 |
| Formula | C10H5N3O3 |
| CAS Number | 118409-62-4 |
| Solubility (25°C) | DMSO: ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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