Free shipping on all orders over $ 500

AG 126

Cat. No. M9300
AG 126 Structure
Synonym:

AG126; Tyrphostin AG 126

Size Price Availability Quantity
5mg USD 87  USD87 In stock
10mg USD 147  USD147 In stock
25mg USD 320  USD320 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

AG 126 is a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. AG 126 selectively inhibits the phosphorylation. AG126 can prevent the activation of mitogen-activated protein kinase p42MAPK (ERK2).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 215.17
Formula C10H5N3O3
CAS Number 118409-62-4
Purity 100.00%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

[1] Marzocco S, et al. Naunyn Schmiedebergs Arch Pharmacol. Tyrphostin AG 126 reduces intestinal ischemia-reperfusion injury in the rat.

[2] Moore BA, et al. Am J Physiol Gastrointest Liver Physiol. Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon.

[3] Dugo L, et al. Intensive Care Med. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat.

Related ERK Products
2,5-Dihydroxyacetophenone

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers used in food flavoring. 2',5'-Dihydroxyacetophenone significantly inhibits the production of NO by inhibiting the expression of iNOS. 2',5'-Dihydroxyacetophenone significantly reduces the expression levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

Tenuifoliside A

Tenuifoliside A is isolated from Yuanzhi and has anti-apoptotic and antidepressant effects. In C6 cells, Tenuifoliside A exhibits its neurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signaling pathway.

Tauroursodeoxycholate dihydrate

Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate significantly reduces the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK.

DMU-212

DMU-212 is a resveratrol methylated derivative with anti-division, antiproliferative, antioxidant and apoptosis-promoting activities. DMU-212 causes mitosis to stop by inducing apoptosis and activating the ERK1/2 protein.

(rel)-AR234960

(rel)-AR234960 is the relatively active configuration of AR234960. AR234960 is a non-peptide MAS (a G protein coupling receptor) agonist that upregulates CTGF mRNA and protein levels through the ERK1/2 signaling pathway in HEK293-MAS cells and adult myocardial fibroblasts.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AG 126, AG126; Tyrphostin AG 126 supplier, ERK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.