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Tauroursodeoxycholate Sodium

Cat. No. M5340
Tauroursodeoxycholate Sodium Structure
Synonym:

TUDCA; Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt

Size Price Availability Quantity
100mg USD 75  USD75 In stock
500mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

In vitro: In vitro, Tauroursodeoxycholate shows protective and reversing effects on 17βEG-induced impairment of the cVA-of-CLF. In Mz-ChA-1 cholangiocarcinoma cells, Tauroursodeoxycholate inhibits cell growth via Ca2+-, PKC-, and MAPK-dependent pathways. In isolated rat hepatocytes, Tauroursodeoxycholate inhibits bile acid-Induced Apoptosis via a β1-integrin-mediated formation of cAMP.

In vivo: In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations.

Chemical Information
Molecular Weight 521.69
Formula C26H44NNaO6S
CAS Number 35807-85-3
Solubility (25°C) DMSO: ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Matsuoka K, et al. Chem Phys Lipids. Micellization of conjugated chenodeoxy- and ursodeoxycholates and solubilization of cholesterol into their micelles: comparison with other four conjugated bile salts species.

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Keywords: Tauroursodeoxycholate Sodium, TUDCA; Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt supplier, ERK, inhibitors, activators


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