| Cat.No. | Name | Information |
|---|---|---|
| M4409 | Coptisine chloride | Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection. |
| M4408 | Coptisine | Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. |
| M4407 | Demethyleneberberine | Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD). |
| M4406 | Phellodendrine | Phellodendrine (Phellodendrine) is an isoquinoline alkaloid, which is one of the important characteristic components in cortex of Phellodendrine Phellodendrine. Phellodendrine regulates the AKT/NF-κB pathway to resist OXIDATIVE stress induced by AAPH. Phellodendrine has good antioxidant and anti-inflammatory effects. |
| M4405 | Obacunone | Obacunone is isolated from swamp white grapefruit seeds and plays an anticancer role by inducing apoptosis. |
| M4403 | Groenlandicine | Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I. |
| M4402 | Epiberberine | Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). |
| M4401 | Columbamine | Columbamine is a quaternary isoquinoline alkaloid isolated from Argemone mexicana. |
| M4400 | Narirutin | Narirutin is one of the active ingredients isolated from Citrus unshiu and has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tuberculosis potency. |
| M4399 | Quercimeritrin | Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is isolated from dentate wormwood leaves and has significant amylase activity. Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus. |
| M4398 | Dimethylfraxetin | Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM. |
| M4397 | Fraxin | Fraxin is a glucoside of fraxetin, an O-methylated coumarin. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme. Fraxin was administered orally to rats to investigate its metabolism. |
| M4396 | Fraxetin | Fraxetin is separate from Cortex Fraxini. Fraxetin has anti-tumor, antioxidant and anti-inflammatory effects. Fraxetin can induce apoptosis. |
| M4395 | Chrysin-7-O-glucoronide | Chrysin-7-O-glucoronide |
| M4394 | Wogonoside | Wogonoside is a flavonoid glycoside isolated from Scutellaria baicalensis and has anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating the MAPK-MTOR pathway. |
| M4393 | Wogonin | Wogonin is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. |
| M4392 | Scutellarin-methylester | Scutellarin Methyl ester is a component of breviscapine, a crude extract of several flavonoids in breviscapine. |
| M4391 | Isoimperatorin | Isoimperatorin is a methanol extract from the root of Angelica dahurica. It effectively inhibits acetylcholinesterase (AChE) with IC50 of 74.6 μM. |
| M4390 | Imperatorin | Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM. |
| M4389 | Carnosol | Carnosol is a phenolic diterpene with antioxidant and anticarcinogenic activities. |
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