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Natural Products

Cat.No.  Name Information
M4418 Sennoside-A Sennoside A is an anthraquinone glycoside found in abundance in the leaves and pods of senna (Cassia Angustifolia). Sennoside A is an HIV-1 inhibitor that inhibits HIV-1 replication.
M4417 7-Epitaxol 7-Epi-Taxol is the active metabolite of Taxol, which has similar effects to Taxol in inhibiting cell proliferation, microtubule dissociation and inducing microtubule polymerization.
M4416 Cephalomannine Cephalomannine is a taxol alkaloid analogue that can be isolated from most tricuspid taxus species. Cephalomannine is an orally active anti-tumor agent that can be used as a chemotherapy agent for cancer research.
M4415 Sesamolin Sesaminol can be isolated from Justicia Orbiculata and has antioxidant activity. Sesaminol inhibits lipid peroxidation and has neuroprotective effect. Sesaminol inhibits MAPK cascade by inhibiting phosphorylation of JNK, P38 MAPKs, and Caspase-3.
M4414 Gentiopicrin Gentiopicroside is a natural iridoid glycoside that can inhibit the activity of P450 with IC50 and Ki values of 61 µM and 22.8 µM for CYP2A6, respectively. Gentiopicroside has anti-inflammatory and antioxidant activities.
M4413 Picroside-III Picroside III is a iridoid glycoside isolated from Picrorhiza Scrophulariiflora (PS), a traditional Chinese medicine.
M4412 Picroside-II Picroside II lutein II is a iridoid compound extracted from Lutein, which has anti-inflammatory and anti-apoptotic effects.
M4411 Picroside-I Picroside I (6' -cinnamoylcatalpol) is a major ingredient of Picrorhiza Kurroa. Picrorhiza Kurroa is a high value medicinal plant rich in liver-protecting metabolites Picroside I and Picroside-II. Picroside I could be used in asthma studies. Picroside I significantly reduces inflammation. Picroside I also down-regulated pSTAT6 and GATA3 expression. Picroside I dose-dependently increases serum IFN-γ levels.
M4410 Coptisine-Sulfate Coptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.
M4409 Coptisine chloride Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection.
M4408 Coptisine Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.
M4407 Demethyleneberberine Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD).
M4406 Phellodendrine Phellodendrine (Phellodendrine) is an isoquinoline alkaloid, which is one of the important characteristic components in cortex of Phellodendrine Phellodendrine. Phellodendrine regulates the AKT/NF-κB pathway to resist OXIDATIVE stress induced by AAPH. Phellodendrine has good antioxidant and anti-inflammatory effects.
M4405 Obacunone Obacunone is isolated from swamp white grapefruit seeds and plays an anticancer role by inducing apoptosis.
M4403 Groenlandicine Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I.
M4402 Epiberberine Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean).
M4401 Columbamine Columbamine is a quaternary isoquinoline alkaloid isolated from Argemone mexicana.
M4400 Narirutin Narirutin is one of the active ingredients isolated from Citrus unshiu and has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tuberculosis potency.
M4399 Quercimeritrin Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is isolated from dentate wormwood leaves and has significant amylase activity. Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) has antibacterial activity, it shows promising activity against Staphylococcus aureus.
M4398 Dimethylfraxetin Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a Ki value of 0.0097 μM.

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