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Protosappanin-B

Cat. No. M4490
Protosappanin-B Structure
Size Price Availability Quantity
20mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Protosappanin B is a polyphenol substance extracted from Sappanwood, which has anti-tumor effect. In human bladder cancer cells, it can induce apoptosis by arresting G1 phase of cell cycle.

Chemical Information
Molecular Weight 304.29
Formula C16H16O6
CAS Number 102036-29-3
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei-Ying Chen, et al. UPLC-ESI-Q-TOF/MS Based Metabolic Profiling of Protosappanin B in Rat Plasma, Bile, Feces, Urine and Intestinal Bacteria Samples

[2] Xue-Cong Zheng, et al. Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression

[3] Xihua Yang, et al. Protosappanin B promotes apoptosis and causes G 1 cell cycle arrest in human bladder cancer cells

[4] Xihua Yang, et al. Antitumor Effects of Purified Protosappanin B Extracted From Lignum Sappan

[5] Ke-Wu Zeng, et al. Protosappanin B protects PC12 cells against oxygen-glucose deprivation-induced neuronal death by maintaining mitochondrial homeostasis via induction of ubiquitin-dependent p53 protein degradation

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Keywords: Protosappanin-B supplier, Apoptosis, inhibitors, activators


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