| Cat.No. | Name | Information |
|---|---|---|
| M4608 | Swertiamarin | Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. |
| M4607 | Phloretin | Phloretin (NSC 407292; RJC 02792) is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). |
| M4606 | Phloridzin | Phloridzin is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. |
| M4605 | Aucubin | Aucubin is a iridoid glycoside that can be extracted from many traditional herbs. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antibacterial, anti-fibrosis, anti-cancer, liver protection, neuroprotection and bone protection. |
| M4604 | Catalpol | Catalpol (Catalpinoside), is a kind of irisin found in Rehmannia glutinosa, with neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-convulsive, antioxidant and anti-HBV effects. |
| M4603 | D-(-)-Quinic-acid | D-(-)-Quinic-acid is a cyclohexanecarboxylic acid. |
| M4602 | p-Coumaric-acid | P -Coumaric acid is an isomer of cinnamic acid, which has anti-tumor and anti-mutagenic activities. |
| M4600 | Synephrine | Synephrine is an alkaloid from Citrus aurantium that is also an agonist of adrenoceptors. |
| M4599 | Arbutin | Arbutin (β -arbutin) is a natural polyphenol isolated from the bear fruit plant Arctostaphylos uvaursi with antioxidant, anti-inflammatory and anti-tumor properties. It is a competitive inhibitor of tyrosinase in melanocytes, with a Kiapp value of 1.42 mM for monopholase. The value of p-diphenol enzyme Kiapp was 0.9 mM. Arbutin is also used as a bleaching agent. |
| M4598 | Rhoifolin | RhoifolinRhoifolin is a flavonoid glycoside isolated from the leaves of Guanxi pomelo (Citrus Grandis). Rhoifolin is beneficial to diabetic complications by enhancing adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and translocation of GLUT4. Rhoifolin ameliorates titanium-stimulated osteolysis and attenuates osteoclast formation through ranKL-induced NF-κB and MAPK pathways. |
| M4597 | Silicristin | Silychristin is a flavonoid rich in milk thistle fruits, which has antioxidant effects. Silychristin is an effective inhibitor of thyroid hormone transporter MCT8 and can strongly inhibit T3 uptake with IC50 of 110 nM. |
| M4596 | Silydianin | Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. |
| M4595 | Isosilybin | Isosilybin (Isosilybinin) is a flavonoid from milk thistle; The IC50 value induced by CYP3A4 inhibition was 74 μM. |
| M4594 | Cytisine | Cytisinicline (Cytisine) is an alkaloid that can be extracted from Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs), and also a partial agonist of α4β2 and α7 receptors. It has been used medically to help people quit smoking. |
| M4593 | Yohimbine-Hydrochloride | Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. |
| M4592 | Xylitol | Xylitol can be classified as polyols and sugar alcohols. |
| M4591 | Sodium-Aescinate | Sodium Aescinate is a triterpenoid saponin from Aesculus hippocastanum seeds with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits liver cancer growth by targeting the CARMA3/NF-κB pathway. |
| M4590 | Buddleoside | Buddleoside |
| M4589 | Luteolin | Luteolin (Luteolol) is a natural flavonoid that is a modulator of Nrf2. Luteolin exhibits dual regulation of Nrf2. In tumour cells, low concentrations of Luteolin activate the Nrf2 signalling pathway and promote Nrf2 nuclear translocation, while high concentrations of Luteolin inhibit Nrf2 activity and negatively modulate the Nrf2/ARE signalling pathway. Luteolin is also a PDE inhibitor. In addition, Luteolin has a variety of biological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotection. Luteolin can be used in studies related to ferroptosis. |
| M4588 | Astilbin | Astilbin is a flavonoid that enhances NRF2 activation. Astilbin also inhibited TNF-α expression and NF-κB activation. |
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