Rhoifolin is a flavonoid glycoside isolated from the leaves of Guanxi pomelo (Citrus Grandis). Rhoifolin is beneficial to diabetic complications by enhancing adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and translocation of GLUT4. Rhoifolin ameliorates titanium-stimulated osteolysis and attenuates osteoclast formation through ranKL-induced NF-κB and MAPK pathways.
| Molecular Weight | 578.52 |
| Formula | C27H30O14 |
| CAS Number | 17306-46-6 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Jiyuan Yan, et al. Rhoifolin Ameliorates Osteoarthritis via Regulating Autophagy
[4] Seri Jo, et al. Inhibition of SARS-CoV 3CL protease by flavonoids
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