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Kaempferitrin

Cat. No. M4100
Kaempferitrin Structure
Synonym:

Lespedin,-Lespenephryl

Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 230  USD230 In stock
20mg USD 350  USD350 In stock
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Quality Control & Documentation
Biological Activity

Kaempferitrin is a natural flavonoid glycoside with pain relief, anti-inflammatory, anti-diabetes, anti-tumor and other effects, and can activate insulin signaling.

Chemical Information
Molecular Weight 578.52
Formula C27H30O14
CAS Number 482-38-2
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dinesh Kumar Patel. Pharmacological Activities and Therapeutic Potential of Kaempferitrin in Medicine for the Treatment of Human Disorders: A Review of Medicinal Importance and Health Benefits

[2] Wei-Chi Ku, et al. Kaempferitrin-Treated HepG2 Differentially Expressed Exosomal Markers and Affect Extracellular Vesicle Sizes in the Secretome

[3] Jing Wang, et al. Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes

[4] Luisa Helena Cazarolli, et al. Insulin signaling: a potential signaling pathway for the stimulatory effect of kaempferitrin on glucose uptake in skeletal muscle

[5] Sameer Urgaonkar, et al. Synthesis of kaempferitrin

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Keywords: Kaempferitrin, Lespedin,-Lespenephryl supplier, Insulin Receptor, inhibitors, activators


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