About 21 results found for searched term "TNF-α-IN-8" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42833 | TNF-α-IN-8 | Others |
| TNF-α-IN-8 is a TNF-α inhibitor. | ||
| M4066 | Ginsenoside-Rb3 | NF-κB |
| Gypenoside IV | ||
| Ginsenoside Rb3 is derived from Panax Notoginseng. Ginsenoside Rb3 inhibited NF-κB transcriptional activity induced by TNFα in 293T cell lines with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibited the induction of COX-2 and iNOS mRNA. | ||
| M4075 | Ginsenoside-Rd | NF-κB |
| Gypenoside VIII | ||
| Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. | ||
| M4179 | Neochlorogenic-acid | NF-κB |
| trans-5-O-Caffeoylquinic acid | ||
| Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid can inhibit the production of TNF-α and IL-1β. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibited the activation of phosphorylated NF-κB P65 and P38 MAPK. | ||
| M4502 | Mulberroside A | TNF Receptor |
| Mulberroside A is one of the main bioactive components in Mulberry (Morus alba L.). Mulberroside A reduced the expression of TNF-α, IL-1β and IL-6, inhibited the activation of NALP3, Caspase-1 and NF-κB, and phosphorylated ERK, JNK and P38. Mulberroside A has anti-inflammatory and anti-apoptotic effects. | ||
| M4680 | Mollugin | NF-κB |
| Rubimaillin | ||
| Mollugin is Rubia Cordifolia L. Is a major bioactive ingredient in the. Mollugin has anticancer effects by inhibiting NF-κB activation induced by TNF-α. Mollugin can enhance the osteogenic effect of BMP-2 through the P38-Smad signaling pathway. | ||
| M5105 | MD2-TLR4-IN-1 | TLR |
| MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. | ||
| M7189 | Resiquimod | TLR |
| R848; S28463 | ||
| Resiquimod (R-848) is a agonist of Toll-like receptors 7 and 8 (TLR7/TLR8) that induces upregulation of cytokines such as TNF-α, IL-6 and IFN-α. R848 (Resiquimod) induces differential TLR7 and/or TLR8 responses in human and murine immune cells. R848 (Resiquimod) acts as a selective activating ligand for both TLR7 and TLR8 in humans but only TLR7 in mice. It activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway with the subsequent activation of the transcription factors NF-κB and interferon regulatory factor (IRF). | ||
| M10687 | YQ128 | NLR |
| YQ128 is a potent, selective second-generation NLRP3 inflammatory body inhibitor,IC50 0.30 μM. YQ128 significantly and selectively inhibits the production of IL-1β, but does not inhibit the production of TNF-α. YQ128 can cross the blood-brain barrier to reach the central nervous system. YQ128 has anti-inflammatory activity. | ||
| M10949 | C 87 | Others |
| C87 is a novel small molecule inhibitor of TNFα; Efficient inhibition of TNFα-induced cytotoxicity,IC50 The value is 8.73 μM. | ||
| M11003 | Benpyrine | Others |
| Benpyrine is a highly specific orally active TNF-α inhibitor.KD The value is 82.1 μM. Benpyrine binds tightly to TNF-α and blocks its interaction with TNFR1,IC50 The value is 0.109 μM. | ||
| M15037 | Recombinant Mouse IP-10/CXCL10 (E. coli) | Cytokines and Growth Factors |
| Small inducible cytokine B10; CXCL10 | ||
| Interferon inducible protein 10 (IP-10)/CXCL10 was originally thought to be an IFN-γ- inducible gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Protein structure: CXCL10 (ILE22-PRO98), Accession # :Q548V9. | ||
| M15038 | Recombinant Human IP-10/CXCL10 (E. coli) | Cytokines and Growth Factors |
| Small inducible cytokine B10; CXCL10 | ||
| IP-10 /CXCL10, also known as CXCL10, was originally thought to be an IFN-γ- induced gene in monocytes, fibroblasts, and endothelial cells. LPS, IL-1β, TNF-α, IL-12 and virus can also induce the expression of IP-10 mRNA. Expressed with an N-terminal Met. CXCL10 (VAL22-PRO98), Accession # :P02778. | ||
| M21166 | Recombinant Human IL32 (E.coli) | Cytokines and Growth Factors |
| Natural killer cells protein 4；Tumor necrosis factor alpha-inducing factor | ||
| It induces various cytokines such as TNFA/TNF-α and IL8. it activates the typical cytokine signaling pathways NF-kappa-B and p38 MAPK. accession # P24001. | ||
| M22238 | Emetine dihydrochloride hydrate | Autophagy |
| Emetine dihydrochloride hydrate is an alkaloid that has been found in ipecac root and has diverse biological activities. Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells. | ||
| M28790 | cis-Mulberroside A | TNF Receptor |
| Mulberroside D | ||
| cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM. | ||
| M29615 | SR-318 | p38 MAPK |
| SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity. | ||
| M39210 | 7,8-Didehydrocimigenol | NF-κB |
| 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis. | ||
| M39221 | Sootepin D | NF-κB |
| Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC50 of 8.3μM. Sootepin D has anti-inflammatory activity. | ||
| M40637 | TD-1092 | IAP |
| TD-1092 is a pan-inhibitor of apoptosis (IAP) degrader with two different types of E3 ligase conjugates, IAP and CRBN, that induces proteasomal degradation of cIAP2 and XIAP in a CRBN-dependent manner. TD1092 also activates apoptotic proteases (apoptosis 3/7) and leads to apoptosis by promoting IAP degradation. In addition, TD1092 also blocks the TNFα-mediated NF-κB signaling pathway and inhibits the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can be used as a PROTAC for cancer research. | ||
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
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