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Recombinant Human IL32 (E.coli)

Cat. No. M21166
Recombinant Human IL32 (E.coli) Structure
Synonym:

Natural killer cells protein 4;Tumor necrosis factor alpha-inducing factor

Size Price Availability Quantity
50ug USD 400  USD400 In stock
100ug USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

Genus: Human
Expression system: E.coli
Purity: >95% as determined by SDS-PAGE
Protein Construct: DNA sequence encoding human IL32 (Ala31-Lys234) fused with His tag
Predicted molecular weight: 25.56 kDa
Storage and Stability: Use a manually thawed refrigerator to avoid repeated freeze-thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for 12 months from date of receipt.

Bioactivity: It induces various cytokines such as TNFA/TNF-α and IL8. it activates the typical cytokine signaling pathways NF-kappa-B and p38 MAPK.

Chemical Information
Solubility (25°C) Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products
please refer to it for details.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhao-ju Tian, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. [Cloning and expression of human interleukin-32 and studies on its bioactivity]

[2] Siyoung Lee, et al. Hybridoma (Larchmt). Interleukin-32 gamma specific monoclonal antibody and developing IL-32 specific ELISA

[3] Jun Jaekal, et al. Vet Immunol Immunopathol. Cloning and characterization of bovine interleukin-32 beta isoform

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Keywords: Recombinant Human IL32 (E.coli), Natural killer cells protein 4;Tumor necrosis factor alpha-inducing factor supplier, Recombinant Proteins, inhibitors, activators


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