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SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity.
| Molecular Weight | 459.58 |
| Formula | C27H33N5O2 |
| CAS Number | 2413286-32-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 125 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light |
[2] Sandra Röhm, et al. Eur J Med Chem. Selective targeting of the αC and DFG-out pocket in p38 MAPK
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