Certificate of Analysis
| Product Name: | SR-318 |
| Catalog Number: | M29615 |
| CAS Number: | 2413286-32-3 |
Physical and Chemical Properties
| Formula: | C27H33N5O2 |
| Molecular Weight: | 459.58 |
| Form: | Solid |
| Solubility: | DMSO 125 mg/mL (ultrasonic) |
| Storage: | 4°C, protect from light |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |