About 30 results found for searched term "SI-2" (0.005 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1768 | Rapamycin | mTOR |
| Sirolimus; Rapamune; AY-22989 | ||
| Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. | ||
| M1772 | PKI-587 | PI3K |
| Gedatolisib; PF-05212384 | ||
| PKI-587 (Gedatolisib; PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with the IC50 value of 0.4nM. | ||
| M1879 | XL147 | PI3K |
| Pilaralisib; SAR245408 | ||
| XL147 (SAR245408) is an orally bioavailable, selective small molecule Class I PI3K kinase family inhibitor. | ||
| M1972 | Iniparib | PARP |
| BSI-201, NSC-746045, IND-71677 | ||
| Iniparib is an irreversible, noncompetitive inhibitor of PARP1 that disrupts binding between PARP1 and DNA by interacting with the DNA binding domain. | ||
| M1989 | CHIR-99021 HCl | GSK-3 |
| Laduviglusib hydrochloride; CHIR-99021 hydrochloride | ||
| CHIR-99021 HCl (Laduviglusib; CT99021) is a hydrochloride of CHIR-99021, with IC50 of 10 nM and 6.7 nM for GSK-3α and GSK-3β, respectively. | ||
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2099 | OSI-027 | mTOR |
| OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively. | ||
| M2191 | Forskolin | Adenylate Cyclase |
| Coleonol; Colforsin; HL 362 | ||
| Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. | ||
| M2220 | GDC-0941 Bimesylate | PI3K |
| Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC-0941 | ||
| GDC-0941 Bimesylate is the orally bioavailable bismesylate salt of a potent inhibitor of the class I phosphatidylinositol 3 kinase (PI3K). | ||
| M2326 | Etoposide (VP-16-213) | Topoisomerase |
| VP-16-213; Vepesid; NSC 141540 | ||
| Etoposide (VP-16-213) is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity. | ||
| M2403 | MDK83190 | Caspase |
| Apoptosis Activator 2; MDK-83190 | ||
| MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. | ||
| M3173 | Potassium canrenoate | Mineralocorticoid Receptor |
| Aldadiene potassium, SC-14266 | ||
| Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension. | ||
| M3491 | OSI-420 | EGFR/HER2 |
| Desmethyl Erlotinib; CP-473420 | ||
| OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM). | ||
| M3998 | Rhein | FTO |
| Cassic acid; Rheic Acid; Monorhein; NSC 38629 | ||
| Rhein, also known as cassic acid, is a substance in the anthraquinone group obtained from rhubarb. | ||
| M1562 | PSI-6206 | Anti-infection |
| RO 2433; RO2433; RO-2433 | ||
| PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM. | ||
| M4054 | Mogroside-IIA2 | Others |
| Mogroside II-A2 is a triterpenoid glycoside, which is a non-saccharide sweetener. Mogroside is sweeter than sucrose. Mogroside has antioxidant, anti-diabetic and anticancer activities. | ||
| M4065 | Ginsenoside-Rb2 | Anti-infection |
| Ginsenoside C | ||
| Ginsenoside Rb2 is one of the main bioactive components of ginseng extract. Ginsenoside Rb2 can up-regulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects. | ||
| M4067 | Ginsenoside-Rg2 | NF-κB |
| Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2 | ||
| Ginsenoside-Rg2 is one of the major active components of ginseng, acts as a NF-κB inhibitor. | ||
| M4069 | (S)Ginsenoside-Rh1 | PPAR |
| Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1; Ginsenoside-Rh1 | ||
| Ginsenoside Rh1 (Prosapogenin A2) inhibited the expression of PPAR-γ, TNF-α, IL-6 and IL-1β. | ||
| M4070 | (S)Ginsenoside-Rh2 | Caspase |
| 20(S)-Ginsenoside Rh2; 20(S)-Rh2; Ginsenoside-Rh2 | ||
| (S)Ginsenoside-Rh2 is isolated from the root of Ginseng, induces the activation of caspase-8 and caspase-9. | ||
| M4071 | Pseudoginsenoside-Rh2 | Others |
| Pseudoginsenoside Rh2 is synthesized by Ginsenoside Rh2 and has antitumor activity. | ||
| M4074 | Ginsenoside-Re | Amyloid |
| Ginsenoside B2; Panaxoside Re; Chikusetsusaponin IVc; Sanchinoside Re | ||
| Ginsenoside Re (Ginsenoside B2) is a ginseng - ginseng extract. Ginsenoside Re reduces beta-amyloid (Aβ). Ginsenoside Re also exerts anti-inflammatory effects by inhibiting JNK and NF-κB. | ||
| M4079 | (R)Ginsenoside-Rh2 | MMP |
| 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as an anti-proliferative agent in cells. It has anticancer effects by blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis and has anti-inflammatory and antioxidant activities. 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of mouse and human γ herpevirus 68 (MHV-68) with an IC50 of 2.77 μM against mouse MHV-68. | ||
| M4080 | (R)Ginsenoside-Rg2 | Others |
| 20(R) -ginsenoside Rg2 is a Ginsenoside. 20(R)-Ginsenoside Rg2 has an inhibitory effect on lung cancer NCI-H1650 cells. It has anti-cancer activity. | ||
| M4084 | Ginsenoside-F2 | Apoptosis |
| Ginsenoside F2, a metabolite of Ginsenoside Rb1, induces apoptosis and protective autophagy in breast cancer stem cells. | ||
| M4103 | 20(S)-Notoginsenoside-R2 | Others |
| 20(R)-Notoginsenoside R2 is a saponin isolated from Panax Notoginseng. | ||
| M4104 | 20(S)-NotoginsenosideR2 | Apoptosis |
| 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2 | ||
| Notoginsenoside R2(Notoginsenoside R2) is a newly isolated panax Notoginsenoside R2, which showed protective effects against oxidative stress and cell apoptosis induced by 6-OHDA. | ||
| M4163 | β-Sitosterol | Liposome |
| β-Sitosterol; 22,23-Dihydrostigmasterol; Beta-Sitosterol | ||
| Replacing cholesterol in lipid nanoparticle (LNP) formulations with β-Sitosterol, a natural phytosterol, significantly improves mRNA delivery. | ||
| M4254 | (+)Gomisin-M2 | Others |
| CAS# 100759-78-2 | ||
| (+)Gomisin-M2 | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
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