About 31 results found for searched term "SCR7" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4807 | SCR7 | DNA/RNA Synthesis |
| SCR-7 | ||
| SCR7 is a specific DNA Ligase IV inhibitor. | ||
| M8572 | SCR7 pyrazine | CRISPR/Cas9 |
| SCR7 pyrazine is reported to be an inhibitor of non-homologous end joining (NHEJ) and has been shown to enhance the efficiency of CRISPR-Cas9 genome editing. | ||
| M51429 | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | Others |
| Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a TIF-2 coactivator peptide composed of 14 amino acids and covers the residue range 740-753 of TIF-2 protein. | ||
| M2786 | JSH-23 | NF-κB |
| Jsh-23 is a NF-κB inhibitor, inhibited NF-κB transcriptional activity in lipopolysaccharid-stimulated macrophages RAW 264.7 with IC50 of 7.1 μM. Jsh-23 inhibited the nuclear translocation of NF-κB P65 without affecting the degradation of IκBα. | ||
| M3342 | Emtricitabine | Reverse Transcriptase |
| BW1592 | ||
| Emtricitabine is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. | ||
| M3352 | Lamivudine (BCH-189) | Reverse Transcriptase |
| BCH-189 | ||
| Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. | ||
| M4075 | Ginsenoside-Rd | NF-κB |
| Gypenoside VIII | ||
| Ginsenoside Rd inhibited NF-κB transcriptional activity induced by TNFα with IC50 of 12.05±0.82 μM. Ginsenoside Rd inhibited the expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibited CYP2D6, CYP1A2, CYP3A4 and CYP2C9 with IC50 of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM and 85.1±9.1 μM, respectively. | ||
| M5807 | Napabucasin (BBI608) | STAT |
| BBI608; BB608 | ||
| Napabucasin (BBI608) is a first-in-class, orally active inhibitor of Stat3 that blocks stem cell activity in cancer cells by targeting the signal transducer and activator of transcription 3 pathway. Napabucasin inhibits cell proliferation of U87MG tumor xenografts in mice. | ||
| M10863 | NCGC00378430 | Others |
| NCGC00378430 is a potent inhibitor of the SIX1/EYA2 interaction. NCGC00378430 partially reverses SIX1 overexpression-mediated transcription and metabolic profiling, and reverses SIX1-induced TGF-β signaling and epithelial-interstitial transformation (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in mouse models. | ||
| M10960 | Ralaniten | Androgen Receptor |
| EPI-002 | ||
| Ralaniten (EPI-002) is an effective and orally active androgen receptor N-terminal domain (AR-NTD) antagonist. Ralaniten inhibits AR transcriptional activity,IC50 The value is 7.4 μM. Ralanites can be used in the study of castration-resistant prostate cancer (CRPC). | ||
| M11441 | CFT7455 | Ligand for E3 Ligase |
| Cemsidomide | ||
| CFT7455 is an orally active inhibitor of zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3). CFT7455 is an anticancer agent that binds cereblon E3 ligase with high affinity (Kd 0.9 nM) (WO2022032132A1; Compound 1). | ||
| M11512 | CBL0137 hydrochloride | p53 |
| Curaxin-137 hydrochloride; CBL-C137 hydrochloride | ||
| CBL0137 hydrochloride is an inhibitor of FACT, the histone molecule chaperone. FACT promotes the formation of chromatin transcription complexes. CBL0137 hydrochlorideye also activated p53 and inhibited NF-κB, with EC50 values of 0.37 and 0.47 μM, respectively. | ||
| M13679 | CCT251236 | HSP |
| CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. | ||
| M20577 | Doravirine | Reverse Transcriptase |
| MK1439 | ||
| Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. | ||
| M21214 | AS-0141 | CDK |
| Cdc7-IN-6 | ||
| AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with antitumor activity as described in WO2019165473A1, compound I-D. Cdc7 is a serine threonine protein kinase enzyme that is essential for the initiation of DNA replication during the cell cycle. | ||
| M21415 | Trabectedin | ROS |
| Ecteinascidin 743; ET-743 | ||
| Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid that binds to the minor groove of DNA, blocks stress-induced transcription of proteins, induces DNA backbone cleavage and apoptosis, and increases ROS production in MCF-7 and MDA-MB-453 cells. Trabectedin can be used in soft tissue sarcoma and ovarian cancer studies. | ||
| M21426 | BRD-K98645985 | HIV Protease |
| BRD-K98645985 is a mammalian SWI/SNF transcriptional repressor inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complex, prevents nucleosome localization, effectively reverses HIV-1 latency, and has no T-cell toxicity. | ||
| M24696 | Ascrinvacumab | ALK |
| Anti-ACVRL1/ALK-1 Reference Antibody; PF-03446962 | ||
| Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC). | ||
| M27721 | Nevirapine-d3 | HIV Protease |
| d3 | ||
| Nevirapine-d3 (BI-RG 587-d3) is the deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM. | ||
| M27932 | SRTCX1002 | Sirtuin |
| SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively. | ||
| M28194 | (±)-ML 209 | ROR |
| (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells. | ||
| M28317 | Ro24-7429 | HIV Protease |
| Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects. | ||
| M29069 | BPN-15477 | Others |
| BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research. | ||
| M29224 | Stafib-2 | STAT |
| Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability. | ||
| M29293 | EPI-7170 | Androgen Receptor |
| EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC). | ||
| M29579 | CCT373566 | Bcl-2 |
| CCT373566 is a potent and orally active degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo. | ||
| M29932 | AZ10397767 | CXCR |
| AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC50 of 1 nM. AZ10397767 attenuates the Oxaliplatin-induced NF-κB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo. | ||
| M30812 | S-777469 | Cannabinoid |
| S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism. | ||
| M39852 | Physalin H | Hedgehog |
| Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively. | ||
| M40694 | RIG012 | Others |
| RIG012 is a potent RIG-I antagonist that blocks RIG-I-initiated signaling, inhibits transcriptional induction of CXCL10, IFN-β 1, and IRF9, and reduces IL6 mRNA levels. The IC50 was 0.71 μM when assayed with NADH-coupled ATPase. | ||
| M49566 | Itacnosertib | JAK |
| Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871. | ||
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